Gene description for Klrd1
Gene name killer cell lectin-like receptor, subfamily D, member 1
Gene symbol Klrd1
Other names/aliases CD94
Species Mus musculus
 Database cross references - Klrd1
ExoCarta ExoCarta_16643
Entrez Gene 16643
UniProt O54707  
 Klrd1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Klrd1
Molecular Function
    MHC class Ib protein binding, via antigen binding groove GO:0023030 ISO
    MHC class I protein complex binding GO:0023024 ISO
    protein antigen binding GO:1990405 ISO
    carbohydrate binding GO:0030246 IEA
Biological Process
    natural killer cell mediated immunity GO:0002228 ISO
Subcellular Localization
    receptor complex GO:0043235 ISO
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 IEA
    external side of plasma membrane GO:0009897 IDA
 Experiment description of studies that identified Klrd1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Klrd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Klrd1 is involved
PathwayEvidenceSource
DAP12 interactions IEA Reactome
DAP12 signaling IEA Reactome





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