Gene description for Kras
Gene name v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Gene symbol Kras
Other names/aliases AI929937
Species Mus musculus
 Database cross references - Kras
ExoCarta ExoCarta_16653
Entrez Gene 16653
UniProt P32883  
 Kras identified in exosomes derived from the following tissue/cell type
Embryonic fibroblasts 18494037    
Mast cells 17486113    
 Gene ontology annotations for Kras
Molecular Function
    nucleotide binding GO:0000166 IEA
    protein complex binding GO:0032403 ISO
    protein binding GO:0005515 IPI
    GMP binding GO:0019002 ISO
    LRR domain binding GO:0030275 ISO
    GTP binding GO:0005525 IEA
    GTPase activity GO:0003924 TAS
    GDP binding GO:0019003 ISO
Biological Process
    striated muscle cell differentiation GO:0051146 IGI
    cytokine-mediated signaling pathway GO:0019221 ISO
    positive regulation of Rac protein signal transduction GO:0035022 IGI
    small GTPase mediated signal transduction GO:0007264 IEA
    negative regulation of neuron apoptotic process GO:0043524 IGI
    positive regulation of gene expression GO:0010628 ISO
    positive regulation of protein phosphorylation GO:0001934 ISO
    Ras protein signal transduction GO:0007265 TAS
    regulation of synaptic transmission, GABAergic GO:0032228 IGI
    actin cytoskeleton organization GO:0030036 IGI
    homeostasis of number of cells within a tissue GO:0048873 IGI
    regulation of long-term neuronal synaptic plasticity GO:0048169 IGI
    visual learning GO:0008542 IGI
    negative regulation of cell differentiation GO:0045596 IDA
    signal transduction GO:0007165 IEA
    positive regulation of nitric-oxide synthase activity GO:0051000 ISO
    positive regulation of cell proliferation GO:0008284 ISO
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO
    positive regulation of MAP kinase activity GO:0043406 ISO
    epithelial tube branching involved in lung morphogenesis GO:0060441 IGI
Subcellular Localization
    intracellular GO:0005622 IGI
    membrane GO:0016020 ISO
    mitochondrion GO:0005739 ISO
    cytoplasm GO:0005737 ISO
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 ISO
    plasma membrane GO:0005886 IEA
    focal adhesion GO:0005925 ISO
    membrane raft GO:0045121 ISO
 Experiment description of studies that identified Kras in exosomes
Experiment ID 73
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 18494037    
Organism Mus musculus
Experiment description Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.
Authors Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ
Journal name ELEC
Publication year 2008
Sample Embryonic fibroblasts
Sample name NIH3T3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA]
Western blotting
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for Kras
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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