Gene description for CFD
Gene name complement factor D (adipsin)
Gene symbol CFD
Other names/aliases ADIPSIN
ADN
DF
PFD
Species Homo sapiens
 Database cross references - CFD
ExoCarta ExoCarta_1675
Entrez Gene 1675
HGNC 2771
MIM 134350
UniProt P00746  
 CFD identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for CFD
Molecular Function
    serine-type peptidase activity GO:0008236 TAS
    serine-type endopeptidase activity GO:0004252 IEA
Biological Process
    platelet activation GO:0030168 TAS
    complement activation GO:0006956 TAS
    complement activation, alternative pathway GO:0006957 TAS
    innate immune response GO:0045087 TAS
    blood coagulation GO:0007596 TAS
    platelet degranulation GO:0002576 TAS
    proteolysis GO:0006508 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IEA
    platelet alpha granule lumen GO:0031093 TAS
 Experiment description of studies that identified CFD in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CFD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SERPINF2 5345
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which CFD is involved
PathwayEvidenceSource
Alternative complement activation TAS Reactome
Platelet degranulation TAS Reactome





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