Gene description for Dsg4
Gene name desmoglein 4
Gene symbol Dsg4
Other names/aliases CDHF13
Species Mus musculus
 Database cross references - Dsg4
ExoCarta ExoCarta_16769
Entrez Gene 16769
UniProt Q7TMD7  
 Dsg4 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Dsg4
Molecular Function
    metal ion binding GO:0046872 IEA
    calcium ion binding GO:0005509 ISO
Biological Process
    keratinocyte differentiation GO:0030216 IMP
    hair follicle development GO:0001942 IDA
    single organismal cell-cell adhesion GO:0016337 IMP
    anagen GO:0042640 IMP
    BMP signaling pathway GO:0030509 IDA
    cell adhesion GO:0007155 IEA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
Subcellular Localization
    membrane GO:0016020 IEA
    cell junction GO:0030054 IEA
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 IEA
    desmosome GO:0030057 IMP
 Experiment description of studies that identified Dsg4 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Dsg4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dsg4 is involved
No pathways found

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