Gene description for Dsg4
Gene name desmoglein 4
Gene symbol Dsg4
Other names/aliases CDHF13
lah
Species Mus musculus
 Database cross references - Dsg4
ExoCarta ExoCarta_16769
Vesiclepedia VP_16769
Entrez Gene 16769
UniProt Q7TMD7  
 Dsg4 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Dsg4
Molecular Function
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 IEA
    calcium ion binding GO:0005509 ISO
Biological Process
    hair follicle development GO:0001942 IDA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    keratinocyte differentiation GO:0030216 IMP
    BMP signaling pathway GO:0030509 IDA
    anagen GO:0042640 IMP
    cell-cell adhesion GO:0098609 IBA
    cell-cell adhesion GO:0098609 IMP
Subcellular Localization
    plasma membrane GO:0005886 IEA
    desmosome GO:0030057 IBA
    desmosome GO:0030057 IMP
 Experiment description of studies that identified Dsg4 in sEVs
1
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Dsg4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Dsg4 is involved
PathwayEvidenceSource
Developmental Biology IEA Reactome
Formation of the cornified envelope IEA Reactome
Keratinization IEA Reactome





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