Gene description for Lhx2
Gene name LIM homeobox protein 2
Gene symbol Lhx2
Other names/aliases LH2A
Lh-2
Lim2
ap
apterous
Species Mus musculus
 Database cross references - Lhx2
ExoCarta ExoCarta_16870
Entrez Gene 16870
UniProt Q9Z0S2  
 Lhx2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Lhx2
Molecular Function
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    chromatin binding GO:0003682 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    DNA binding GO:0003677 IEA
    metal ion binding GO:0046872 IEA
    RNA polymerase II transcription factor binding transcription factor activity GO:0001076 IPI
    sequence-specific DNA binding GO:0043565 IDA
Biological Process
    brain development GO:0007420 IMP
    negative regulation of transcription regulatory region DNA binding GO:2000678 IGI
    telencephalon regionalization GO:0021978 IMP
    transcription from RNA polymerase II promoter GO:0006366 IPI
    nervous system development GO:0007399 IMP
    axon guidance GO:0007411 IMP
    dorsal/ventral pattern formation GO:0009953 IMP
    regulation of transcription from RNA polymerase II promoter GO:0006357 IPI
    telencephalon development GO:0021537 IMP
    retina development in camera-type eye GO:0060041 IGI
    hair follicle development GO:0001942 IMP
    neuron differentiation GO:0030182 IMP
    cerebral cortex development GO:0021987 IMP
    mesoderm development GO:0007498 IMP
    neurogenesis GO:0022008 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IGI
    anatomical structure formation involved in morphogenesis GO:0048646 IMP
    olfactory bulb development GO:0021772 IMP
    axon extension GO:0048675 IDA
    neural tube closure GO:0001843 IMP
    regulation of transcription, DNA-templated GO:0006355 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    maintenance of epithelial cell apical/basal polarity GO:0045199 IMP
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    intracellular GO:0005622 IDA
 Experiment description of studies that identified Lhx2 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Lhx2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lhx2 is involved
No pathways found





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