Gene description for Elovl6
Gene name ELOVL family member 6, elongation of long chain fatty acids (yeast)
Gene symbol Elovl6
Other names/aliases C77826
FAE
LCE
Species Mus musculus
 Database cross references - Elovl6
ExoCarta ExoCarta_170439
Entrez Gene 170439
UniProt Q920L5  
 Elovl6 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Elovl6
Molecular Function
    transferase activity GO:0016740 IEA
    fatty acid elongase activity GO:0009922 ISO
    transferase activity, transferring acyl groups other than amino-acyl groups GO:0016747 IDA
Biological Process
    fatty acid elongation GO:0030497 IDA
    lipid metabolic process GO:0006629 IEA
    fatty acid biosynthetic process GO:0006633 IEA
    fatty acid elongation, saturated fatty acid GO:0019367 ISO
    fatty acid metabolic process GO:0006631 IEA
    long-chain fatty acid biosynthetic process GO:0042759 ISO
Subcellular Localization
    integral component of endoplasmic reticulum membrane GO:0030176 IDA
    membrane GO:0016020 IEA
    endoplasmic reticulum GO:0005783 ISO
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Elovl6 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Elovl6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Elovl6 is involved
PathwayEvidenceSource
Activation of gene expression by SREBF (SREBP) IEA Reactome
Synthesis of very long-chain fatty acyl-CoAs IEA Reactome





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