Gene description for Snx18
Gene name sorting nexin 18
Gene symbol Snx18
Other names/aliases Snag1
Species Mus musculus
 Database cross references - Snx18
ExoCarta ExoCarta_170625
Vesiclepedia VP_170625
Entrez Gene 170625
 Snx18 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Snx18
Molecular Function
    phosphatidylinositol binding GO:0035091 IDA
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISO
    lipid binding GO:0008289 IEA
    protein binding GO:0005515 IPI
Biological Process
    cleavage furrow formation GO:0036089 ISO
    endosomal transport GO:0016197 ISO
    cell cycle GO:0007049 IEA
    protein transport GO:0015031 IEA
    vesicle organization GO:0016050 IBA
    transport GO:0006810 IEA
    cell division GO:0051301 IEA
    positive regulation of GTPase activity GO:0043547 ISO
    mitotic cytokinesis GO:0000281 ISO
    mitotic nuclear division GO:0007067 IEA
    intracellular protein transport GO:0006886 IEA
    endocytosis GO:0006897 ISO
Subcellular Localization
    endosome GO:0005768 IBA
    cytoplasmic membrane-bounded vesicle GO:0016023 ISO
    clathrin-coated vesicle GO:0030136 ISO
    membrane GO:0016020 IEA
    extracellular exosome GO:0070062 ISO
    extrinsic component of membrane GO:0019898 IBA
    neuronal cell body GO:0043025 IDA
    cytoplasmic vesicle GO:0031410 IEA
    plasma membrane GO:0005886 IEA
    growth cone GO:0030426 IDA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 ISO
 Experiment description of studies that identified Snx18 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Snx18
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Snx18 is involved
No pathways found





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