Gene description for Stk17b
Gene name serine/threonine kinase 17b
Gene symbol Stk17b
Other names/aliases Drak2
Species Rattus norvegicus
 Database cross references - Stk17b
ExoCarta ExoCarta_170904
Entrez Gene 170904
UniProt Q91XS8  
 Stk17b identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Stk17b
Molecular Function
    protein serine/threonine kinase activity GO:0004674 TAS
    protein binding GO:0005515 IPI
    protein kinase activity GO:0004672 IDA
    ATP binding GO:0005524 ISS
Biological Process
    positive regulation of fibroblast apoptotic process GO:2000271 ISS
    apoptotic process GO:0006915 IMP
    protein autophosphorylation GO:0046777 IDA
    programmed cell death GO:0012501 IDA
    protein phosphorylation GO:0006468 ISS
    intracellular signal transduction GO:0035556 ISS
Subcellular Localization
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IEA
    actin cytoskeleton GO:0015629 IMP
    nucleus GO:0005634 ISS
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified Stk17b in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Stk17b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Stk17b is involved
No pathways found





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