Gene description for Sumo2
Gene name SMT3 suppressor of mif two 3 homolog 2 (yeast)
Gene symbol Sumo2
Other names/aliases SUMO-2
Smt3A
Smt3b
Smt3h2
Species Mus musculus
 Database cross references - Sumo2
ExoCarta ExoCarta_170930
Vesiclepedia VP_170930
Entrez Gene 170930
UniProt P61957  
 Sumo2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Sumo2
Molecular Function
    protein binding GO:0005515 IPI
    SUMO transferase activity GO:0019789 IDA
    protein tag activity GO:0031386 IBA
    ubiquitin protein ligase binding GO:0031625 ISO
    ubiquitin protein ligase binding GO:0031625 ISS
    ubiquitin-like protein ligase binding GO:0044389 IBA
    nuclear retinoid X receptor binding GO:0046965 ISO
Biological Process
    protein localization GO:0008104 ISO
    protein sumoylation GO:0016925 IBA
    protein sumoylation GO:0016925 IDA
    protein sumoylation GO:0016925 ISO
    protein sumoylation GO:0016925 ISS
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IEA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISO
    positive regulation of protein sumoylation GO:0033235 ISO
    negative regulation of DNA-templated transcription GO:0045892 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 IGI
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 TAS
    PML body GO:0016605 ISO
    PML body GO:0016605 ISS
    hippocampal mossy fiber to CA3 synapse GO:0098686 IDA
    hippocampal mossy fiber to CA3 synapse GO:0098686 IEP
    presynapse GO:0098793 IDA
    presynapse GO:0098793 IEP
    postsynapse GO:0098794 IDA
    postsynapse GO:0098794 IEP
    glutamatergic synapse GO:0098978 IDA
    GABA-ergic synapse GO:0098982 IDA
    GABA-ergic synapse GO:0098982 IEP
    presynaptic cytosol GO:0099523 IDA
    postsynaptic cytosol GO:0099524 IDA
 Experiment description of studies that identified Sumo2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Sumo2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Gli2  
Two-hybrid Mus musculus
2 Atg16l1  
Affinity Capture-MS Mus musculus
3 Daxx  
Co-crystal Structure Mus musculus
Reconstituted Complex Mus musculus
4 Ccnb1ip1  
Two-hybrid Mus musculus
View the network image/svg+xml



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