Gene description for Slc31a1
Gene name solute carrier family 31 (copper transporter), member 1
Gene symbol Slc31a1
Other names/aliases Ctr1
LRRGT00200
Species Rattus norvegicus
 Database cross references - Slc31a1
ExoCarta ExoCarta_171135
Vesiclepedia VP_171135
Entrez Gene 171135
UniProt Q9JK41  
 Slc31a1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Slc31a1
Molecular Function
    copper ion transmembrane transporter activity GO:0005375 IDA
    copper ion transmembrane transporter activity GO:0005375 IEA
    copper ion transmembrane transporter activity GO:0005375 ISO
    copper ion binding GO:0005507 IEA
    copper ion binding GO:0005507 ISO
    copper ion binding GO:0005507 ISS
    silver ion transmembrane transporter activity GO:0015080 IEA
    silver ion transmembrane transporter activity GO:0015080 ISO
    silver ion transmembrane transporter activity GO:0015080 ISS
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    xenobiotic transmembrane transporter activity GO:0042910 IEA
    xenobiotic transmembrane transporter activity GO:0042910 ISO
    xenobiotic transmembrane transporter activity GO:0042910 ISS
Biological Process
    angiogenesis GO:0001525 IEA
    angiogenesis GO:0001525 ISO
    angiogenesis GO:0001525 ISS
    copper ion transport GO:0006825 ISO
    intracellular copper ion homeostasis GO:0006878 IEA
    intracellular copper ion homeostasis GO:0006878 ISO
    copper ion import GO:0015677 IDA
    copper ion import GO:0015677 IEA
    copper ion import GO:0015677 ISO
    copper ion import GO:0015677 ISO
    plasma membrane copper ion transport GO:0015679 IEA
    plasma membrane copper ion transport GO:0015679 ISO
    plasma membrane copper ion transport GO:0015679 ISS
    copper ion transmembrane transport GO:0035434 IEA
    vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 IEA
    vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 ISO
    vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 ISS
    xenobiotic transport GO:0042908 IEA
    xenobiotic transport GO:0042908 ISO
    xenobiotic transport GO:0042908 ISS
    protein complex oligomerization GO:0051259 IEA
    protein complex oligomerization GO:0051259 ISO
    protein complex oligomerization GO:0051259 ISS
    establishment of localization in cell GO:0051649 IEA
    establishment of localization in cell GO:0051649 ISO
    transmembrane transport GO:0055085 IDA
    cellular response to cisplatin GO:0072719 IDA
    copper ion import across plasma membrane GO:0098705 IMP
    silver ion transmembrane transport GO:1902601 IEA
    silver ion transmembrane transport GO:1902601 ISO
    silver ion transmembrane transport GO:1902601 ISS
Subcellular Localization
    late endosome GO:0005770 ISO
    plasma membrane GO:0005886 ISO
    intercalated disc GO:0014704 IEA
    intercalated disc GO:0014704 ISO
    basolateral plasma membrane GO:0016323 IEA
    basolateral plasma membrane GO:0016323 ISO
    basolateral plasma membrane GO:0016323 ISS
    apical plasma membrane GO:0016324 IDA
    apical plasma membrane GO:0016324 IEA
    apical plasma membrane GO:0016324 ISO
    early endosome membrane GO:0031901 IEA
    early endosome membrane GO:0031901 ISO
    early endosome membrane GO:0031901 ISS
    late endosome membrane GO:0031902 IEA
    neuronal cell body GO:0043025 IDA
    recycling endosome GO:0055037 ISO
    recycling endosome membrane GO:0055038 IEA
    recycling endosome membrane GO:0055038 ISO
    recycling endosome membrane GO:0055038 ISS
 Experiment description of studies that identified Slc31a1 in sEVs
1
Experiment ID 90
MISEV standards
EM
Biophysical techniques
HSC70|HSP90|TSG101|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Slc31a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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