Gene description for Slc31a1
Gene name solute carrier family 31 (copper transporter), member 1
Gene symbol Slc31a1
Other names/aliases Ctr1
LRRGT00200
Species Rattus norvegicus
 Database cross references - Slc31a1
ExoCarta ExoCarta_171135
Entrez Gene 171135
UniProt Q9JK41  
 Slc31a1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Slc31a1
Molecular Function
    copper uptake transmembrane transporter activity GO:0015088 ISO
    copper ion transmembrane transporter activity GO:0005375 IMP
Biological Process
    drug transmembrane transport GO:0006855 IDA
    copper ion import GO:0015677 ISO
    cellular copper ion homeostasis GO:0006878 ISO
    copper ion import into cell GO:1902861 IMP
    cellular response to cisplatin GO:0072719 IDA
    copper ion transmembrane transport GO:0035434 ISO
Subcellular Localization
    recycling endosome GO:0055037 ISO
    cell GO:0005623 ISO
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    integral component of membrane GO:0016021 IEA
    neuronal cell body GO:0043025 IDA
    late endosome GO:0005770 ISO
 Experiment description of studies that identified Slc31a1 in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Slc31a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc31a1 is involved
PathwayEvidenceSource
Metal ion SLC transporters IEA Reactome





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