Gene description for Serpina10
Gene name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
Gene symbol Serpina10
Other names/aliases Rasp1
Species Rattus norvegicus
 Database cross references - Serpina10
ExoCarta ExoCarta_171154
Entrez Gene 171154
UniProt Q62975  
 Serpina10 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Serpina10
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 IBA
    heparin binding GO:0008201 IEA
Biological Process
    negative regulation of endopeptidase activity GO:0010951 IBA
    regulation of acrosome reaction GO:0060046 ISO
    blood coagulation GO:0007596 IEA
    tissue regeneration GO:0042246 IEP
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Serpina10 in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Serpina10
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Serpina10 is involved
No pathways found





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