Gene description for Mgst1
Gene name microsomal glutathione S-transferase 1
Gene symbol Mgst1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Mgst1
ExoCarta ExoCarta_171341
Entrez Gene 171341
UniProt P08011  
 Mgst1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Hepatocytes 19367702    
 Gene ontology annotations for Mgst1
Molecular Function
    glutathione transferase activity GO:0004364 TAS
    glutathione peroxidase activity GO:0004602 ISO
    identical protein binding GO:0042802 IDA
    protein homodimerization activity GO:0042803 IDA
    glutathione binding GO:0043295 IDA
Biological Process
    response to organonitrogen compound GO:0010243 IDA
    cellular response to lipid hydroperoxide GO:0071449 ISO
    response to drug GO:0042493 IDA
    Leydig cell differentiation GO:0033327 IEP
    response to lipopolysaccharide GO:0032496 IDA
    glutathione metabolic process GO:0006749 ISO
    protein homotrimerization GO:0070207 IDA
    oxidation-reduction process GO:0055114 ISO
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    mitochondrial inner membrane GO:0005743 ISO
    nucleus GO:0005634 IDA
    mitochondrial outer membrane GO:0005741 IEA
    endoplasmic reticulum GO:0005783 IDA
    mitochondrion GO:0005739 ISO
    integral component of membrane GO:0016021 IDA
    apical part of cell GO:0045177 IDA
    peroxisomal membrane GO:0005778 IDA
 Experiment description of studies that identified Mgst1 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Mgst1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mgst1 is involved
PathwayEvidenceSource
Aflatoxin activation and detoxification IEA Reactome
Glutathione conjugation IEA Reactome





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