Gene description for Pabpc1
Gene name poly(A) binding protein, cytoplasmic 1
Gene symbol Pabpc1
Other names/aliases Pabp
Pabp1
Species Rattus norvegicus
 Database cross references - Pabpc1
ExoCarta ExoCarta_171350
Entrez Gene 171350
UniProt Q9EPH8  
 Pabpc1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Pabpc1
Molecular Function
    poly(A) binding GO:0008143 ISS
    nucleotide binding GO:0000166 IEA
    protein C-terminus binding GO:0008022 ISO
    mRNA binding GO:0003729 IDA
    protein binding GO:0005515 IPI
    poly(U) RNA binding GO:0008266 ISO
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213 ISS
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 IEA
    negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:2000623 ISS
    gene silencing by RNA GO:0031047 ISS
    mRNA processing GO:0006397 IEA
    RNA splicing GO:0008380 IEA
    positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153 ISS
Subcellular Localization
    cytoplasmic ribonucleoprotein granule GO:0036464 ISO
    extracellular exosome GO:0070062 ISO
    focal adhesion GO:0005925 ISO
    membrane GO:0016020 ISO
    ribonucleoprotein complex GO:0030529 ISS
    messenger ribonucleoprotein complex GO:1990124 IDA
    cytoplasmic stress granule GO:0010494 ISS
    dendrite GO:0030425 IDA
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    catalytic step 2 spliceosome GO:0071013 ISO
 Experiment description of studies that identified Pabpc1 in exosomes
1
Experiment ID 94
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Pabpc1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pabpc1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here