|
 Gene description for Mical1 |
| Gene name |
microtubule associated monooxygenase, calponin and LIM domain containing 1 |
| Gene symbol |
Mical1 |
| Other names/aliases |
MICAL
MICAL-1
Nical |
| Species |
Mus musculus |
| Database cross references - Mical1 |
| ExoCarta |
ExoCarta_171580 |
| Vesiclepedia |
VP_171580 |
| Entrez Gene |
171580 |
| UniProt |
Q8VDP3
|
| Mical1 identified in exosomes derived from the following tissue/cell type |
|
Colon cancer cells
|
37309723
|
|
T-cell lymphoma cells
|
37309723
|
| Gene ontology annotations for Mical1 |
| Molecular Function |
| |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
GO:0016709 |
ISO |
|
| |
1-methylnaphthalene hydroxylase activity |
GO:0034534 |
IEA |
|
| |
Rab GTPase binding |
GO:0017137 |
IPI |
|
| |
3,5-xylenol methylhydroxylase activity |
GO:0018630 |
IEA |
|
| |
phenanthrene 9,10-monooxygenase activity |
GO:0018636 |
IEA |
|
| |
3-(3-hydroxyphenyl)propionate hydroxylase activity |
GO:0008688 |
IEA |
|
| |
phenanthrene 1,2-monooxygenase activity |
GO:0018647 |
IEA |
|
| |
alpha-pinene monooxygenase [NADH] activity |
GO:0018634 |
IEA |
|
| |
3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity |
GO:0018653 |
IEA |
|
| |
1-hydroxy-2-oxolimonene 1,2-monooxygenase activity |
GO:0018646 |
IEA |
|
| |
tetrahydrofuran hydroxylase activity |
GO:0018649 |
IEA |
|
| |
4-hydroxypyridine-3-hydroxylase activity |
GO:0034894 |
IEA |
|
| |
xylene monooxygenase activity |
GO:0018639 |
IEA |
|
| |
6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity |
GO:0018641 |
IEA |
|
| |
2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity |
GO:0018655 |
IEA |
|
| |
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity |
GO:0043719 |
IEA |
|
| |
actin binding |
GO:0003779 |
ISO |
|
| |
toluene-sulfonate methyl-monooxygenase activity |
GO:0018652 |
IEA |
|
| |
2-hydroxy-phenylacetate hydroxylase activity |
GO:0018654 |
IEA |
|
| |
toluene 2-monooxygenase activity |
GO:0018644 |
IEA |
|
| |
toluene-4-sulfonate monooxygenase activity |
GO:0018651 |
IEA |
|
| |
phenanthrene 3,4-monooxygenase activity |
GO:0018656 |
IEA |
|
| |
chlorophenol 4-monooxygenase activity |
GO:0018642 |
IEA |
|
| |
styrene monooxygenase activity |
GO:0018650 |
IEA |
|
| |
toluene 4-monooxygenase activity |
GO:0018638 |
IEA |
|
| |
branched-chain dodecylbenzene sulfonate monooxygenase activity |
GO:0034802 |
IEA |
|
| |
monooxygenase activity |
GO:0004497 |
IMP |
|
| |
tocotrienol omega-hydroxylase activity |
GO:0052872 |
IEA |
|
| |
phenylacetate hydroxylase activity |
GO:0018631 |
IEA |
|
| |
1-hydroxy-2-naphthoate hydroxylase activity |
GO:0018637 |
IEA |
|
| |
3-HSA hydroxylase activity |
GO:0034819 |
IEA |
|
| |
zinc ion binding |
GO:0008270 |
IEA |
|
| |
isobutylamine N-hydroxylase activity |
GO:0034791 |
IEA |
|
| |
4-chlorobenzaldehyde oxidase activity |
GO:0018471 |
IEA |
|
| |
6-hydroxynicotinate 3-monooxygenase activity |
GO:0043731 |
IEA |
|
| |
dimethyl sulfide monooxygenase activity |
GO:0018633 |
IEA |
|
| |
bisphenol A hydroxylase A activity |
GO:0034560 |
IEA |
|
| |
dibenzothiophene monooxygenase activity |
GO:0018640 |
IEA |
|
| |
carbon disulfide oxygenase activity |
GO:0018643 |
IEA |
|
| |
toluene 3-monooxygenase activity |
GO:0018657 |
IEA |
|
| |
oxidoreductase activity |
GO:0016491 |
IEA |
|
| |
SH3 domain binding |
GO:0017124 |
ISO |
|
| |
limonene monooxygenase activity |
GO:0019113 |
IEA |
|
| |
protein binding |
GO:0005515 |
IPI |
|
| |
salicylate 5-hydroxylase activity |
GO:0034785 |
IEA |
|
| |
4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity |
GO:0018660 |
IEA |
|
| |
2-methylnaphthalene hydroxylase activity |
GO:0034526 |
IEA |
|
| |
4-nitrophenol 4-monooxygenase activity |
GO:0018632 |
IEA |
|
| |
metal ion binding |
GO:0046872 |
IEA |
|
| |
thalianol hydroxylase activity |
GO:0080014 |
IEA |
|
| |
FAD binding |
GO:0071949 |
ISO |
|
| Biological Process |
| |
actin filament depolymerization |
GO:0030042 |
ISO |
|
| |
negative regulation of protein phosphorylation |
GO:0001933 |
IMP |
|
| |
oxidation-reduction process |
GO:0055114 |
ISO |
|
| |
negative regulation of apoptotic process |
GO:0043066 |
IMP |
|
| |
sulfur oxidation |
GO:0019417 |
IDA |
|
| |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
GO:0043154 |
IMP |
|
| |
cytoskeleton organization |
GO:0007010 |
IEA |
|
| Subcellular Localization |
| |
cytoskeleton |
GO:0005856 |
IEA |
|
| |
cytoplasm |
GO:0005737 |
ISO |
|
|
| Experiment description of studies that identified Mical1 in exosomes |
| 1 |
| Experiment ID |
907 |
| MISEV standards |
|
✔
EM
|
EV Biophysical techniques |
|
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
|
EV Enriched markers |
|
✔
HSPA5
|
EV Negative markers |
|
✔
NTA
|
EV Particle analysis
|
|
| Identified molecule |
Protein
|
| Identification method |
Mass spectrometry
|
| PubMed ID |
37309723
|
| Organism |
Mus musculus |
| Experiment description |
Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells |
| Authors |
Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S. |
| Journal name |
Proteomics
|
| Publication year |
2023 |
| Sample |
Colon cancer cells |
| Sample name |
C26 |
| Isolation/purification methods |
Differential centrifugation
Ultracentrifugation |
| Flotation density |
-
|
| Molecules identified in the study |
Protein |
| Methods used in the study |
Western blotting
Mass spectrometry |
|
|
| 2 |
| Experiment ID |
908 |
| MISEV standards |
|
✔
EM
|
EV Biophysical techniques |
|
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
|
EV Enriched markers |
|
✔
HSPA5
|
EV Negative markers |
|
✔
NTA
|
EV Particle analysis
|
|
| Identified molecule |
Protein
|
| Identification method |
Mass spectrometry
|
| PubMed ID |
37309723
|
| Organism |
Mus musculus |
| Experiment description |
Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells |
| Authors |
Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S. |
| Journal name |
Proteomics
|
| Publication year |
2023 |
| Sample |
T-cell lymphoma cells |
| Sample name |
EL4 |
| Isolation/purification methods |
Differential centrifugation
Ultracentrifugation |
| Flotation density |
-
|
| Molecules identified in the study |
Protein |
| Methods used in the study |
Western blotting
Mass spectrometry |
|
|
| Protein-protein interactions for Mical1 |
| |
Protein Interactor |
ExoCarta ID |
Identification method |
PubMed |
Species |
|
No interactions are found.
|
|
| Pathways in which Mical1 is involved |
|
No pathways found
|
|
|
