Gene description for Cma1
Gene name chymase 1, mast cell
Gene symbol Cma1
Other names/aliases MMCP-5
Mcp-5
Mcp5
Mcpt5
Species Mus musculus
 Database cross references - Cma1
ExoCarta ExoCarta_17228
Vesiclepedia VP_17228
Entrez Gene 17228
UniProt P21844  
 Cma1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cma1
Molecular Function
    endopeptidase activity GO:0004175 ISO
    serine-type endopeptidase activity GO:0004252 IBA
    serine-type endopeptidase activity GO:0004252 IEA
    serine-type endopeptidase activity GO:0004252 ISO
    serine-type peptidase activity GO:0008236 ISO
    peptide binding GO:0042277 ISO
Biological Process
    proteolysis GO:0006508 IEA
    protein processing GO:0016485 ISO
    extracellular matrix disassembly GO:0022617 ISO
    protein catabolic process GO:0030163 ISO
    basement membrane disassembly GO:0034769 ISO
    positive regulation of angiogenesis GO:0045766 ISO
    regulation of inflammatory response GO:0050727 ISO
    protein maturation GO:0051604 IBA
    cytokine precursor processing GO:0140447 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular region GO:0005576 ISO
    extracellular space GO:0005615 IBA
    intracellular anatomical structure GO:0005622 IDA
    cytosol GO:0005829 ISO
    secretory granule GO:0030141 ISO
    cytoplasmic ribonucleoprotein granule GO:0036464 ISO
 Experiment description of studies that identified Cma1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cma1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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