Gene description for Cma1
Gene name chymase 1, mast cell
Gene symbol Cma1
Other names/aliases MMCP-5
Mcp-5
Mcp5
Mcpt5
Species Mus musculus
 Database cross references - Cma1
ExoCarta ExoCarta_17228
Entrez Gene 17228
UniProt P21844  
 Cma1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cma1
Molecular Function
    serine-type peptidase activity GO:0008236 IEA
    peptide binding GO:0042277 ISO
    serine-type endopeptidase activity GO:0004252 ISO
    peptidase activity GO:0008233 IEA
    hydrolase activity GO:0016787 IEA
Biological Process
    interleukin-1 beta biosynthetic process GO:0050720 ISO
    proteolysis GO:0006508 ISO
    positive regulation of angiogenesis GO:0045766 ISO
    protein processing GO:0016485 IBA
Subcellular Localization
    extracellular matrix GO:0031012 ISO
    intracellular GO:0005622 IDA
    extracellular region GO:0005576 ISO
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified Cma1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cma1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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