Gene description for Abcc1
Gene name ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Gene symbol Abcc1
Other names/aliases Abcc1a
Abcc1b
MRP
Mdrap
Mrp1
Species Mus musculus
 Database cross references - Abcc1
ExoCarta ExoCarta_17250
Entrez Gene 17250
UniProt O35379  
 Abcc1 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Abcc1
Molecular Function
    glutathione transmembrane transporter activity GO:0034634 ISO
    xenobiotic-transporting ATPase activity GO:0008559 ISO
    ATP binding GO:0005524 IEA
    ATPase activity GO:0016887 ISO
    ATPase activity, coupled to transmembrane movement of substances GO:0042626 IEA
    efflux transmembrane transporter activity GO:0015562 ISO
    lipid-transporting ATPase activity GO:0034040 ISO
    glutathione S-conjugate-exporting ATPase activity GO:0015431 ISO
    long-chain fatty acid transporter activity GO:0005324 ISO
    hydrolase activity GO:0016787 IEA
    sphingolipid transporter activity GO:0046624 ISO
    drug transmembrane transporter activity GO:0015238 ISO
    nucleotide binding GO:0000166 IEA
    transporter activity GO:0005215 IEA
Biological Process
    plasma membrane long-chain fatty acid transport GO:0015911 ISO
    transport GO:0006810 IEA
    positive regulation of cell migration GO:0030335 ISO
    drug transmembrane transport GO:0006855 ISO
    daunorubicin transport GO:0043215 ISO
    cell chemotaxis GO:0060326 ISO
    response to oxidative stress GO:0006979 ISO
    drug export GO:0046618 ISO
    transmembrane transport GO:0055085 ISO
    glutathione transmembrane transport GO:0034775 ISO
    response to drug GO:0042493 ISO
    xenobiotic transport GO:0042908 ISO
    negative regulation of neuron death GO:1901215 ISO
    phospholipid efflux GO:0033700 ISO
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    integral component of plasma membrane GO:0005887 ISO
    membrane GO:0016020 ISO
    basolateral plasma membrane GO:0016323 ISO
    extracellular exosome GO:0070062 ISO
    plasma membrane GO:0005886 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Abcc1 in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Abcc1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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