Gene description for Mef2d
Gene name myocyte enhancer factor 2D
Gene symbol Mef2d
Other names/aliases C80750
Species Mus musculus
 Database cross references - Mef2d
ExoCarta ExoCarta_17261
Entrez Gene 17261
UniProt Q63943  
 Mef2d identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Mef2d
Molecular Function
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    activating transcription factor binding GO:0033613 ISO
    enzyme binding GO:0019899 IPI
    protein dimerization activity GO:0046983 IEA
    sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 ISO
    protein homodimerization activity GO:0042803 IPI
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 ISO
    protein heterodimerization activity GO:0046982 IPI
    histone deacetylase binding GO:0042826 ISO
    DNA binding GO:0003677 IDA
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
Biological Process
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    multicellular organismal development GO:0007275 IEA
    transcription, DNA-templated GO:0006351 IEA
    nervous system development GO:0007399 IEA
    apoptotic process GO:0006915 IEA
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    regulation of transcription, DNA-templated GO:0006355 IDA
    chondrocyte differentiation GO:0002062 IGI
    cell differentiation GO:0030154 IEA
    osteoblast differentiation GO:0001649 IGI
    skeletal muscle cell differentiation GO:0035914 IMP
    endochondral ossification GO:0001958 IGI
    transcription from RNA polymerase II promoter GO:0006366 ISO
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 ISO
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Mef2d in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Mef2d
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mef2d is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here