Gene description for Meis1
Gene name Meis homeobox 1
Gene symbol Meis1
Other names/aliases C530044H18Rik
Evi8
Species Mus musculus
 Database cross references - Meis1
ExoCarta ExoCarta_17268
Entrez Gene 17268
UniProt Q60954  
 Meis1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Meis1
Molecular Function
    DNA binding GO:0003677 IDA
    sequence-specific DNA binding GO:0043565 IGI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 IPI
    chromatin binding GO:0003682 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0003705 IDA
Biological Process
    definitive hemopoiesis GO:0060216 IMP
    megakaryocyte development GO:0035855 IMP
    hemopoiesis GO:0030097 IMP
    multicellular organismal development GO:0007275 IEA
    lens morphogenesis in camera-type eye GO:0002089 IMP
    blood vessel morphogenesis GO:0048514 IMP
    locomotory behavior GO:0007626 IMP
    negative regulation of neuron differentiation GO:0045665 IGI
    transcription from RNA polymerase II promoter GO:0006366 IDA
    regulation of transcription, DNA-templated GO:0006355 IDA
    transcription, DNA-templated GO:0006351 IEA
    angiogenesis GO:0001525 IMP
    negative regulation of myeloid cell differentiation GO:0045638 IDA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IC
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    transcription factor complex GO:0005667 IDA
 Experiment description of studies that identified Meis1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Meis1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Meis1 is involved
No pathways found





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