Gene description for Mmp3
Gene name matrix metallopeptidase 3
Gene symbol Mmp3
Other names/aliases SLN-1
SLN1
STR-1
Stmy1
Str1
Species Mus musculus
 Database cross references - Mmp3
ExoCarta ExoCarta_17392
Vesiclepedia VP_17392
Entrez Gene 17392
UniProt P28862  
 Mmp3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Mmp3
Molecular Function
    endopeptidase activity GO:0004175 ISO
    metalloendopeptidase activity GO:0004222 IBA
    metalloendopeptidase activity GO:0004222 TAS
    peptidase activity GO:0008233 ISO
    peptidase activity GO:0008233 ISS
    metallopeptidase activity GO:0008237 ISO
    zinc ion binding GO:0008270 IEA
    protein-containing complex binding GO:0044877 ISO
Biological Process
    proteolysis GO:0006508 IMP
    proteolysis GO:0006508 ISO
    protein catabolic process GO:0030163 IMP
    extracellular matrix organization GO:0030198 IBA
    regulation of cell migration GO:0030334 IMP
    positive regulation of cell migration GO:0030335 ISO
    collagen catabolic process GO:0030574 IBA
    collagen catabolic process GO:0030574 IEA
    positive regulation of protein-containing complex assembly GO:0031334 IEA
    positive regulation of protein-containing complex assembly GO:0031334 ISO
    cellular response to reactive oxygen species GO:0034614 IMP
    innate immune response GO:0045087 IEA
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IMP
    cellular response to amino acid stimulus GO:0071230 IDA
    cellular response to UV-A GO:0071492 ISO
    cellular response to UV-A GO:0071492 ISS
    negative regulation of reactive oxygen species metabolic process GO:2000378 IEA
    negative regulation of reactive oxygen species metabolic process GO:2000378 ISO
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 ISO
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 IDA
    dendrite GO:0030425 ISO
    extracellular matrix GO:0031012 IEA
    protein-containing complex GO:0032991 ISO
    cell body GO:0044297 ISO
 Experiment description of studies that identified Mmp3 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mmp3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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