Gene description for Mrc2
Gene name mannose receptor, C type 2
Gene symbol Mrc2
Other names/aliases Endo180
mKIAA0709
uPARAP
Species Mus musculus
 Database cross references - Mrc2
ExoCarta ExoCarta_17534
Vesiclepedia VP_17534
Entrez Gene 17534
UniProt Q64449  
 Mrc2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Mrc2
Molecular Function
    collagen binding GO:0005518 ISO
    carbohydrate binding GO:0030246 ISO
    signaling receptor activity GO:0038023 IBA
Biological Process
    endocytosis GO:0006897 IEA
    collagen catabolic process GO:0030574 IEA
    collagen catabolic process GO:0030574 ISO
Subcellular Localization
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 ISO
 Experiment description of studies that identified Mrc2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mrc2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fbn1  
Co-fractionation Mus musculus
2 Pax2  
Co-fractionation Mus musculus
View the network image/svg+xml



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