Gene description for Mup5
Gene name major urinary protein 5
Gene symbol Mup5
Other names/aliases Mup18
Species Mus musculus
 Database cross references - Mup5
ExoCarta ExoCarta_17844
Vesiclepedia VP_17844
Entrez Gene 17844
 Mup5 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Mup5
Molecular Function
    molecular_function GO:0003674 ND
    insulin receptor activity GO:0005009 ISS
    odorant binding GO:0005549 IBA
    pheromone binding GO:0005550 ISS
    small molecule binding GO:0036094 IEA
Biological Process
    energy reserve metabolic process GO:0006112 ISS
    mitochondrion organization GO:0007005 ISS
    biological_process GO:0008150 ND
    insulin receptor signaling pathway GO:0008286 IEA
    aerobic respiration GO:0009060 ISS
    positive regulation of gene expression GO:0010628 ISS
    negative regulation of lipid storage GO:0010888 ISS
    positive regulation of glucose metabolic process GO:0010907 ISS
    heat generation GO:0031649 ISS
    glucose homeostasis GO:0042593 ISS
    locomotor rhythm GO:0045475 ISS
    negative regulation of gluconeogenesis GO:0045721 ISS
    positive regulation of lipid metabolic process GO:0045834 ISS
    negative regulation of DNA-templated transcription GO:0045892 ISS
    negative regulation of lipid biosynthetic process GO:0051055 ISS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS
    negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179 ISS
    cellular response to lipid GO:0071396 ISS
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISS
    nucleus GO:0005634 ISS
    cytosol GO:0005829 ISS
 Experiment description of studies that identified Mup5 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Mup5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mup5 is involved
No pathways found





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