Gene description for Myl6
Gene name myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
Gene symbol Myl6
Other names/aliases ESMLC
LC17
LC17-GI
LC17-NM
LC17A
LC17B
MLC-3
MLC1SM
MLC3SM
MLC3nm
Myln
Species Mus musculus
 Database cross references - Myl6
ExoCarta ExoCarta_17904
Entrez Gene 17904
UniProt Q60605  
 Myl6 identified in exosomes derived from the following tissue/cell type
Microglia 16081791    
 Gene ontology annotations for Myl6
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    motor activity GO:0003774 TAS
    structural constituent of muscle GO:0008307 TAS
Biological Process
    skeletal muscle tissue development GO:0007519 TAS
    muscle filament sliding GO:0030049 TAS
    muscle contraction GO:0006936 TAS
Subcellular Localization
    vesicle GO:0031982 ISO
    brush border GO:0005903 ISO
    myosin complex GO:0016459 TAS
    unconventional myosin complex GO:0016461 IDA
    membrane GO:0016020 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Myl6 in exosomes
1
Experiment ID 14
ISEV standards
✔
EM
EV Biophysical techniques
✔
RAB7|RAB11
EV Cytosolic markers
✔
CD9|CD63|LAMP1|LAMP2
EV Membrane markers
✔
DNM
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for Myl6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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