Gene description for Myl6
Gene name myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
Gene symbol Myl6
Other names/aliases ESMLC
LC17
LC17-GI
LC17-NM
LC17A
LC17B
MLC-3
MLC1SM
MLC3SM
MLC3nm
Myln
Species Mus musculus
 Database cross references - Myl6
ExoCarta ExoCarta_17904
Vesiclepedia VP_17904
Entrez Gene 17904
UniProt Q60605  
 Myl6 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Microglia 16081791    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Myl6
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    motor activity GO:0003774 TAS
    structural constituent of muscle GO:0008307 TAS
Biological Process
    skeletal muscle tissue development GO:0007519 TAS
    muscle filament sliding GO:0030049 TAS
    muscle contraction GO:0006936 TAS
Subcellular Localization
    vesicle GO:0031982 ISO
    brush border GO:0005903 ISO
    myosin complex GO:0016459 TAS
    unconventional myosin complex GO:0016461 IDA
    membrane GO:0016020 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Myl6 in exosomes
1
Experiment ID 907
MISEV standards
EM
EV Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
HSPA5
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 14
MISEV standards
EM
EV Biophysical techniques
RAB7|RAB11|CD9|CD63|LAMP1|LAMP2
EV Enriched markers
DNM
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
3
Experiment ID 908
MISEV standards
EM
EV Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
HSPA5
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Myl6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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