Gene description for Neo1
Gene name neogenin
Gene symbol Neo1
Other names/aliases 2610028H22Rik
AI327052
D930014N22Rik
Igdcc2
Species Mus musculus
 Database cross references - Neo1
ExoCarta ExoCarta_18007
Vesiclepedia VP_18007
Entrez Gene 18007
 Neo1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Neo1
Molecular Function
    protein binding GO:0005515 IPI
    signaling receptor activity GO:0038023 IPI
    co-receptor binding GO:0039706 IEA
    co-receptor binding GO:0039706 ISO
    cadherin binding GO:0045296 IDA
    BMP receptor binding GO:0070700 IPI
Biological Process
    neuron migration GO:0001764 IBA
    regulation of DNA-templated transcription GO:0006355 IDA
    intracellular iron ion homeostasis GO:0006879 IMP
    cell adhesion GO:0007155 IEA
    axon guidance GO:0007411 IBA
    myoblast fusion GO:0007520 IMP
    protein secretion GO:0009306 IDA
    positive regulation of BMP signaling pathway GO:0030513 IGI
    regulation of axon regeneration GO:0048679 IGI
    negative regulation of axon regeneration GO:0048681 IMP
    negative regulation of protein secretion GO:0050709 IDA
    multicellular organismal-level iron ion homeostasis GO:0060586 ISO
    cell-cell adhesion GO:0098609 IBA
    trans-synaptic signaling, modulating synaptic transmission GO:0099550 IDA
    trans-synaptic signaling, modulating synaptic transmission GO:0099550 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    membrane GO:0016020 IDA
    growth cone GO:0030426 IDA
    neuronal cell body GO:0043025 ISO
    intracellular vesicle GO:0097708 IDA
    plasma membrane protein complex GO:0098797 IEA
    plasma membrane protein complex GO:0098797 ISO
    postsynaptic density membrane GO:0098839 IDA
    postsynaptic density membrane GO:0098839 IMP
    postsynaptic density membrane GO:0098839 NAS
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    glutamatergic synapse GO:0098978 NAS
 Experiment description of studies that identified Neo1 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Neo1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sstr3  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Neo1 is involved
No pathways found





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