Gene description for Slc11a1
Gene name	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Gene symbol	Slc11a1
Other names/aliases	Bcg Ity Lsh Nramp Nramp1 ity
Species	Mus musculus
Database cross references - Slc11a1
ExoCarta	ExoCarta_18173
Vesiclepedia	VP_18173
Entrez Gene	18173
UniProt	P41251
Slc11a1 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Slc11a1

Molecular Function     iron ion transmembrane transporter activity GO:0005381 IBA     iron ion transmembrane transporter activity GO:0005381 IDA     iron ion transmembrane transporter activity GO:0005381 ISO     manganese ion transmembrane transporter activity GO:0005384 IBA     manganese ion transmembrane transporter activity GO:0005384 IDA     manganese ion transmembrane transporter activity GO:0005384 IMP     manganese ion transmembrane transporter activity GO:0005384 ISO     cadmium ion transmembrane transporter activity GO:0015086 IBA     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     transition metal ion transmembrane transporter activity GO:0046915 ISO     metal cation:proton antiporter activity GO:0051139 IBA     metal cation:proton antiporter activity GO:0051139 IDA     metal cation:proton antiporter activity GO:0051139 ISO Biological Process     negative regulation of cytokine production GO:0001818 IMP     positive regulation of cytokine production GO:0001819 IMP     T cell proliferation involved in immune response GO:0002309 IMP     T cell cytokine production GO:0002369 IMP     positive regulation of dendritic cell antigen processing and presentation GO:0002606 IMP     positive regulation of T-helper 1 type immune response GO:0002827 IMP     iron ion transport GO:0006826 IDA     iron ion transport GO:0006826 ISO     manganese ion transport GO:0006828 IBA     manganese ion transport GO:0006828 IDA     manganese ion transport GO:0006828 IMP     manganese ion transport GO:0006828 ISO     intracellular iron ion homeostasis GO:0006879 IMP     intracellular iron ion homeostasis GO:0006879 ISO     phagocytosis GO:0006909 IMP     inflammatory response GO:0006954 IMP     vacuolar acidification GO:0007035 IMP     response to bacterium GO:0009617 IMP     response to bacterium GO:0009617 ISO     positive regulation of gene expression GO:0010628 IMP     nitrite transport GO:0015707 IDA     metal ion transport GO:0030001 IDA     activation of protein kinase activity GO:0032147 IMP     response to lipopolysaccharide GO:0032496 IDA     response to lipopolysaccharide GO:0032496 IMP     response to lipopolysaccharide GO:0032496 ISO     type II interferon production GO:0032609 IMP     interleukin-2 production GO:0032623 IMP     interleukin-3 production GO:0032632 IMP     positive regulation of type II interferon production GO:0032729 IMP     response to type II interferon GO:0034341 IDA     iron ion transmembrane transport GO:0034755 IBA     iron ion transmembrane transport GO:0034755 IEA     wound healing GO:0042060 IMP     macrophage activation GO:0042116 IDA     macrophage activation GO:0042116 IMP     defense response to bacterium GO:0042742 IMP     defense response to protozoan GO:0042832 IMP     MHC class II biosynthetic process GO:0045342 IMP     respiratory burst GO:0045730 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     antigen processing and presentation of peptide antigen GO:0048002 IMP     mRNA stabilization GO:0048255 IMP     positive regulation of phagocytosis GO:0050766 IMP     defense response to Gram-negative bacterium GO:0050829 IMP     establishment of localization in cell GO:0051649 IMP     multicellular organismal-level iron ion homeostasis GO:0060586 IMP     cadmium ion transmembrane transport GO:0070574 IEA     cadmium ion transmembrane transport GO:0070574 ISO     manganese ion transmembrane transport GO:0071421 IEA     cellular detoxification of cadmium ion GO:0098849 IEA     cellular detoxification of cadmium ion GO:0098849 ISO     proton transmembrane transport GO:1902600 IEA     L-arginine transmembrane transport GO:1903826 IDA Subcellular Localization     lysosome GO:0005764 IDA     lysosomal membrane GO:0005765 IBA     lysosomal membrane GO:0005765 IDA     late endosome GO:0005770 IDA     late endosome GO:0005770 IMP     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     endosome membrane GO:0010008 IBA     endosome membrane GO:0010008 IDA     phagocytic vesicle membrane GO:0030670 IBA     phagocytic vesicle membrane GO:0030670 IDA     phagocytic vesicle membrane GO:0030670 IMP     phagocytic vesicle membrane GO:0030670 ISO     late endosome membrane GO:0031902 IDA     tertiary granule membrane GO:0070821 IEA     tertiary granule membrane GO:0070821 ISO