Gene description for Slc11a1
Gene name	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Gene symbol	Slc11a1
Other names/aliases	Bcg Ity Lsh Nramp Nramp1 ity
Species	Mus musculus
Database cross references - Slc11a1
ExoCarta	ExoCarta_18173
Entrez Gene	18173
UniProt	P41251
Slc11a1 identified in exosomes derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Slc11a1

Molecular Function     protein homodimerization activity GO:0042803 ISO     metal ion:proton antiporter activity GO:0051139 ISO     transporter activity GO:0005215 IEA     manganese ion transmembrane transporter activity GO:0005384 IMP     transition metal ion transmembrane transporter activity GO:0046915 ISO Biological Process     MAPK cascade GO:0000165 ISO     nitrite transport GO:0015707 IDA     positive regulation of gene expression GO:0010628 IMP     positive regulation of interferon-gamma production GO:0032729 IMP     iron ion homeostasis GO:0055072 IMP     iron ion transport GO:0006826 ISO     protein import into nucleus, translocation GO:0000060 IMP     defense response to Gram-negative bacterium GO:0050829 IMP     wound healing GO:0042060 IMP     phagocytosis GO:0006909 IMP     manganese ion transport GO:0006828 IMP     mRNA stabilization GO:0048255 IMP     respiratory burst GO:0045730 IDA     positive regulation of cytokine production GO:0001819 IMP     positive regulation of dendritic cell antigen processing and presentation GO:0002606 IMP     activation of protein kinase activity GO:0032147 IMP     positive regulation of phagocytosis GO:0050766 IMP     interleukin-2 production GO:0032623 IMP     interleukin-3 production GO:0032632 IMP     cellular iron ion homeostasis GO:0006879 ISO     multicellular organismal iron ion homeostasis GO:0060586 IMP     manganese ion transmembrane transport GO:0071421 IMP     L-arginine import GO:0043091 IDA     macrophage activation GO:0042116 IMP     response to interferon-gamma GO:0034341 IDA     transport GO:0006810 IEA     response to lipopolysaccharide GO:0032496 ISO     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     defense response to protozoan GO:0042832 IMP     vacuolar acidification GO:0007035 IMP     response to bacterium GO:0009617 ISO     inflammatory response GO:0006954 IMP     ion transport GO:0006811 IEA     T cell cytokine production GO:0002369 IMP     T cell proliferation involved in immune response GO:0002309 IMP     hydrogen ion transmembrane transport GO:1902600 ISO     negative regulation of cytokine production GO:0001818 IMP     MHC class II biosynthetic process GO:0045342 IMP     defense response to bacterium GO:0042742 IMP     cadmium ion transmembrane transport GO:0070574 ISO     antigen processing and presentation of peptide antigen GO:0048002 IMP     positive regulation of T-helper 1 type immune response GO:0002827 IMP     cellular cadmium ion homeostasis GO:0006876 ISO     divalent metal ion export GO:0070839 IDA Subcellular Localization     late endosome GO:0005770 IMP     cell surface GO:0009986 IDA     membrane GO:0016020 IEA     phagocytic vesicle membrane GO:0030670 ISO     lysosome GO:0005764 IDA     vacuole GO:0005773 IMP     integral component of membrane GO:0016021 IEA     tertiary granule membrane GO:0070821 ISO     plasma membrane GO:0005886 ISO     cell outer membrane GO:0009279 IDA     endosome membrane GO:0010008 IDA