Gene description for Nrf1
Gene name nuclear respiratory factor 1
Gene symbol Nrf1
Other names/aliases C87038
D6Ertd415e
Species Mus musculus
 Database cross references - Nrf1
ExoCarta ExoCarta_18181
Entrez Gene 18181
UniProt Q9WU00  
 Nrf1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nrf1
Molecular Function
    DNA binding GO:0003677 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 TAS
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 ISO
Biological Process
    mitochondrion organization GO:0007005 IMP
    transcription from RNA polymerase II promoter GO:0006366 ISO
    response to electrical stimulus GO:0051602 ISO
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 ISO
    transcription factor complex GO:0005667 TAS
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Nrf1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nrf1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nrf1 is involved
PathwayEvidenceSource
Transcriptional activation of mitochondrial biogenesis IEA Reactome





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