Gene description for Nrf1
Gene name nuclear respiratory factor 1
Gene symbol Nrf1
Other names/aliases C87038
D6Ertd415e
Species Mus musculus
 Database cross references - Nrf1
ExoCarta ExoCarta_18181
Vesiclepedia VP_18181
Entrez Gene 18181
UniProt Q9WU00  
 Nrf1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nrf1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISS
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 ISO
    DNA-binding transcription factor activity GO:0003700 TAS
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 ISS
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    mitochondrion organization GO:0007005 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    response to electrical stimulus GO:0051602 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 TAS
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Nrf1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nrf1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nfe2l2  
Affinity Capture-Western Mus musculus
2 Runx2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Nrf1 is involved
No pathways found





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