Gene description for Nrxn2
Gene name neurexin II
Gene symbol Nrxn2
Other names/aliases 6430591O13Rik
mKIAA0921
Species Mus musculus
 Database cross references - Nrxn2
ExoCarta ExoCarta_18190
Vesiclepedia VP_18190
Entrez Gene 18190
 Nrxn2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nrxn2
Molecular Function
    transmembrane signaling receptor activity GO:0004888 IDA
    calcium channel regulator activity GO:0005246 IGI
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    cell adhesion molecule binding GO:0050839 IPI
    neuroligin family protein binding GO:0097109 IPI
Biological Process
    cell adhesion GO:0007155 IEA
    signal transduction GO:0007165 IDA
    chemical synaptic transmission GO:0007268 IGI
    neurotransmitter secretion GO:0007269 IGI
    synapse assembly GO:0007416 IGI
    adult behavior GO:0030534 IEA
    adult behavior GO:0030534 ISO
    social behavior GO:0035176 IEA
    social behavior GO:0035176 ISO
    vocal learning GO:0042297 IEA
    vocal learning GO:0042297 ISO
    vocalization behavior GO:0071625 IEA
    vocalization behavior GO:0071625 ISO
    postsynaptic membrane assembly GO:0097104 IDA
    gephyrin clustering involved in postsynaptic density assembly GO:0097116 IDA
    neuroligin clustering involved in postsynaptic membrane assembly GO:0097118 IDA
    postsynaptic density protein 95 clustering GO:0097119 IDA
    regulation of postsynaptic neurotransmitter receptor activity GO:0098962 IDA
    regulation of postsynaptic neurotransmitter receptor activity GO:0098962 IMP
    presynaptic modulation of chemical synaptic transmission GO:0099171 IDA
    presynaptic modulation of chemical synaptic transmission GO:0099171 IMP
    regulation of postsynapse assembly GO:0150052 IDA
    regulation of postsynapse assembly GO:0150052 IMP
Subcellular Localization
    protein-containing complex GO:0032991 IPI
    presynaptic membrane GO:0042734 ISA
    cell projection GO:0042995 IEA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Nrxn2 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nrxn2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Nrxn2 is involved
No pathways found





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