Gene description for Nsdhl
Gene name NAD(P) dependent steroid dehydrogenase-like
Gene symbol Nsdhl
Other names/aliases AI747449
Bpa
H105E3
Str
XAP104
Species Mus musculus
 Database cross references - Nsdhl
ExoCarta ExoCarta_18194
Entrez Gene 18194
UniProt Q9R1J0  
 Nsdhl identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Nsdhl
Molecular Function
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 IEA
    sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity GO:0047012 IEA
    oxidoreductase activity GO:0016491 IEA
    3-beta-hydroxy-delta5-steroid dehydrogenase activity GO:0003854 IEA
Biological Process
    cholesterol biosynthetic process GO:0006695 IEA
    oxidation-reduction process GO:0055114 IEA
    steroid biosynthetic process GO:0006694 IEA
    cholesterol metabolic process GO:0008203 IMP
    sterol biosynthetic process GO:0016126 IEA
    steroid metabolic process GO:0008202 IEA
    smoothened signaling pathway GO:0007224 IGI
    labyrinthine layer blood vessel development GO:0060716 IMP
    lipid metabolic process GO:0006629 IEA
    hair follicle development GO:0001942 IMP
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 ISO
    integral component of membrane GO:0016021 IEA
    lipid particle GO:0005811 ISO
    membrane GO:0016020 IEA
    endoplasmic reticulum GO:0005783 ISO
 Experiment description of studies that identified Nsdhl in exosomes
1
Experiment ID 264
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Nsdhl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nsdhl is involved
PathwayEvidenceSource
Cholesterol biosynthesis IEA Reactome





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