Gene description for Ddr2
Gene name	discoidin domain receptor family, member 2
Gene symbol	Ddr2
Other names/aliases	AW495251 Ntrkr3 tyro10
Species	Mus musculus
Database cross references - Ddr2
ExoCarta	ExoCarta_18214
Vesiclepedia	VP_18214
Entrez Gene	18214
UniProt	Q62371
Ddr2 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Ddr2

Molecular Function     transmembrane receptor protein tyrosine kinase activity GO:0004714 ISO     transmembrane receptor protein tyrosine kinase activity GO:0004714 ISS     GPI-linked ephrin receptor activity GO:0005004 IEA     transmembrane-ephrin receptor activity GO:0005005 IEA     epidermal growth factor receptor activity GO:0005006 IEA     fibroblast growth factor receptor activity GO:0005007 IEA     hepatocyte growth factor receptor activity GO:0005008 IEA     insulin receptor activity GO:0005009 IEA     insulin-like growth factor receptor activity GO:0005010 IEA     macrophage colony-stimulating factor receptor activity GO:0005011 IEA     platelet-derived growth factor alpha-receptor activity GO:0005018 IEA     platelet-derived growth factor beta-receptor activity GO:0005019 IEA     stem cell factor receptor activity GO:0005020 IEA     vascular endothelial growth factor receptor activity GO:0005021 IEA     collagen binding GO:0005518 IBA     collagen binding GO:0005518 IDA     collagen binding GO:0005518 ISO     collagen binding GO:0005518 ISS     ATP binding GO:0005524 IEA     boss receptor activity GO:0008288 IEA     histone H3Y41 kinase activity GO:0035401 IEA     placental growth factor receptor activity GO:0036332 IEA     protein tyrosine kinase collagen receptor activity GO:0038062 IBA     protein tyrosine kinase collagen receptor activity GO:0038062 IDA     protein tyrosine kinase collagen receptor activity GO:0038062 ISO     brain-derived neurotrophic factor receptor activity GO:0060175 IEA     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     ossification GO:0001503 IEA     endochondral bone growth GO:0003416 IMP     chromatin remodeling GO:0006338 IEA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IDA     epidermal growth factor receptor signaling pathway GO:0007173 IEA     multicellular organism development GO:0007275 IBA     positive regulation of cell population proliferation GO:0008284 IMP     insulin receptor signaling pathway GO:0008286 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 IEA     positive regulation of fibroblast migration GO:0010763 IMP     positive regulation of neuron projection development GO:0010976 IBA     peptidyl-tyrosine phosphorylation GO:0018108 ISO     peptidyl-tyrosine phosphorylation GO:0018108 ISS     collagen fibril organization GO:0030199 IMP     regulation of bone mineralization GO:0030500 ISO     regulation of bone mineralization GO:0030500 ISS     biomineral tissue development GO:0031214 IMP     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA     positive regulation of collagen biosynthetic process GO:0032967 IEA     positive regulation of collagen biosynthetic process GO:0032967 ISO     regulation of tissue remodeling GO:0034103 IEA     regulation of tissue remodeling GO:0034103 ISO     platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA     chondrocyte proliferation GO:0035988 IMP     response to muscle stretch GO:0035994 IEA     vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IDA     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 ISO     vascular endothelial growth factor signaling pathway GO:0038084 IEA     Kit signaling pathway GO:0038109 IEA     macrophage colony-stimulating factor signaling pathway GO:0038145 IEA     negative regulation of apoptotic process GO:0043066 IEA     negative regulation of apoptotic process GO:0043066 ISO     positive regulation of osteoblast differentiation GO:0045669 ISO     positive regulation of osteoblast differentiation GO:0045669 ISS     positive regulation of protein kinase activity GO:0045860 ISO     positive regulation of protein kinase activity GO:0045860 ISS     protein autophosphorylation GO:0046777 IDA     protein autophosphorylation GO:0046777 ISO     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     hepatocyte growth factor receptor signaling pathway GO:0048012 IEA     ephrin receptor signaling pathway GO:0048013 IEA     positive regulation of fibroblast proliferation GO:0048146 IMP     positive regulation of DNA-binding transcription factor activity GO:0051091 ISO     positive regulation of DNA-binding transcription factor activity GO:0051091 ISS     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IBA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     cellular response to hypoxia GO:0071456 IEA     cellular response to transforming growth factor beta stimulus GO:0071560 IEA     positive regulation of extracellular matrix disassembly GO:0090091 IMP     positive regulation of wound healing GO:0090303 IEA     positive regulation of wound healing GO:0090303 ISO     positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IEA     positive regulation of G1/S transition of mitotic cell cycle GO:1900087 ISO     negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 IEA     negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 ISO     cellular response to angiotensin GO:1904385 IEA     positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 IEA     positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 ISO     positive regulation of vascular associated smooth muscle cell migration GO:1904754 IEA     positive regulation of vascular associated smooth muscle cell migration GO:1904754 ISO     positive regulation of hepatic stellate cell proliferation GO:1904899 IEA     positive regulation of hepatic stellate cell proliferation GO:1904899 ISO     positive regulation of hepatic stellate cell activation GO:2000491 IEA     positive regulation of hepatic stellate cell activation GO:2000491 ISO Subcellular Localization     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     actin cytoskeleton GO:0015629 IEA     actin cytoskeleton GO:0015629 ISO     apical plasma membrane GO:0016324 IEA     apical plasma membrane GO:0016324 ISO     receptor complex GO:0043235 IBA