Gene description for Palm
Gene name paralemmin
Gene symbol Palm
Other names/aliases -
Species Mus musculus
 Database cross references - Palm
ExoCarta ExoCarta_18483
Vesiclepedia VP_18483
Entrez Gene 18483
UniProt Q9Z0P4  
 Palm identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Palm
Molecular Function
    D3 dopamine receptor binding GO:0031750 IPI
Biological Process
    cytoskeleton organization GO:0007010 IDA
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 IBA
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 IDA
    negative regulation of adenylate cyclase activity GO:0007194 IDA
    protein localization GO:0008104 IDA
    regulation of cell shape GO:0008360 IDA
    positive regulation of filopodium assembly GO:0051491 IBA
    positive regulation of filopodium assembly GO:0051491 IDA
    positive regulation of filopodium assembly GO:0051491 IEA
    positive regulation of filopodium assembly GO:0051491 ISO
    synapse maturation GO:0060074 IBA
    synapse maturation GO:0060074 IDA
    negative regulation of dopamine receptor signaling pathway GO:0060160 IEA
    negative regulation of dopamine receptor signaling pathway GO:0060160 ISO
    positive regulation of dendritic spine development GO:0060999 IDA
    cellular response to electrical stimulus GO:0071257 IDA
    protein localization to plasma membrane GO:0072659 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    postsynaptic density GO:0014069 IDA
    basolateral plasma membrane GO:0016323 IEA
    basolateral plasma membrane GO:0016323 ISO
    apicolateral plasma membrane GO:0016327 IEA
    apicolateral plasma membrane GO:0016327 ISO
    filopodium GO:0030175 IBA
    filopodium GO:0030175 IDA
    axon GO:0030424 IEA
    axon GO:0030424 ISO
    filopodium membrane GO:0031527 IEA
    filopodium membrane GO:0031527 ISO
    dendrite membrane GO:0032590 ISO
    dendritic spine membrane GO:0032591 ISO
    dendritic spine GO:0043197 IEA
    neuron spine GO:0044309 IBA
    neuron spine GO:0044309 IDA
    synaptic membrane GO:0097060 IBA
    postsynapse GO:0098794 IBA
 Experiment description of studies that identified Palm in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Palm
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Invs  
Affinity Capture-MS Mus musculus
2 Fancd2  
Affinity Capture-MS Mus musculus
3 Kctd13  
Affinity Capture-MS Mus musculus
4 Sstr3  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Palm is involved
No pathways found





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