Gene description for Pax8
Gene name paired box 8
Gene symbol Pax8
Other names/aliases Pax-8
Species Mus musculus
 Database cross references - Pax8
ExoCarta ExoCarta_18510
Entrez Gene 18510
UniProt Q00288  
 Pax8 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Pax8
Molecular Function
    transcription regulatory region DNA binding GO:0044212 ISO
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 ISO
    protein binding GO:0005515 IPI
    sequence-specific DNA binding GO:0043565 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 ISO
    sequence-specific DNA binding transcription factor activity GO:0003700 TAS
    DNA binding GO:0003677 ISS
Biological Process
    multicellular organismal development GO:0007275 IEA
    thyroid gland development GO:0030878 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    cellular response to gonadotropin stimulus GO:0071371 ISO
    mesonephros development GO:0001823 IMP
    positive regulation of thyroid hormone generation GO:2000611 ISO
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    metanephros development GO:0001656 IGI
    negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 IMP
    regulation of thyroid-stimulating hormone secretion GO:2000612 ISO
    metanephric distal convoluted tubule development GO:0072221 IMP
    organ morphogenesis GO:0009887 TAS
    transcription from RNA polymerase II promoter GO:0006366 ISO
    negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 IMP
    transcription, DNA-templated GO:0006351 ISO
    metanephric nephron tubule formation GO:0072289 IMP
    regulation of apoptotic process GO:0042981 IMP
    regulation of transcription, DNA-templated GO:0006355 TAS
    negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 IMP
    positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 IMP
    regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 IMP
    negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 IMP
    inner ear morphogenesis GO:0042472 IGI
    positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 IMP
    pronephros development GO:0048793 IMP
    cell differentiation GO:0030154 IMP
    urogenital system development GO:0001655 IGI
    positive regulation of metanephric DCT cell differentiation GO:2000594 IMP
Subcellular Localization
    transcription factor complex GO:0005667 TAS
    nucleoplasm GO:0005654 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Pax8 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Pax8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pax8 is involved
No pathways found





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