Gene description for Pcolce
Gene name procollagen C-endopeptidase enhancer protein
Gene symbol Pcolce
Other names/aliases Astt-2
Astt2
P14
PCPE-1
Species Mus musculus
 Database cross references - Pcolce
ExoCarta ExoCarta_18542
Entrez Gene 18542
UniProt Q61398  
 Pcolce identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Pcolce
Molecular Function
    heparin binding GO:0008201 ISO
    collagen binding GO:0005518 ISO
    peptidase activator activity GO:0016504 ISO
Biological Process
    proteolysis GO:0006508 IDA
    positive regulation of peptidase activity GO:0010952 ISO
Subcellular Localization
    extracellular space GO:0005615 ISO
    extracellular exosome GO:0070062 ISO
    extracellular region GO:0005576 IEA
    extracellular matrix GO:0031012 ISO
 Experiment description of studies that identified Pcolce in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Pcolce
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pcolce is involved
PathwayEvidenceSource
Collagen biosynthesis and modifying enzymes IEA Reactome





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