Gene description for Pcolce
Gene name procollagen C-endopeptidase enhancer protein
Gene symbol Pcolce
Other names/aliases Astt-2
Species Mus musculus
 Database cross references - Pcolce
ExoCarta ExoCarta_18542
Entrez Gene 18542
UniProt Q61398  
 Pcolce identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Pcolce
Molecular Function
    heparin binding GO:0008201 ISO
    collagen binding GO:0005518 ISO
    peptidase activator activity GO:0016504 ISO
Biological Process
    proteolysis GO:0006508 IDA
    positive regulation of peptidase activity GO:0010952 ISO
Subcellular Localization
    extracellular space GO:0005615 ISO
    extracellular exosome GO:0070062 ISO
    extracellular region GO:0005576 IEA
    extracellular matrix GO:0031012 ISO
 Experiment description of studies that identified Pcolce in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Pcolce
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pcolce is involved
Collagen biosynthesis and modifying enzymes IEA Reactome

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