Gene description for Pdcd4
Gene name programmed cell death 4
Gene symbol Pdcd4
Other names/aliases D19Ucla1
Ma3
Tis
Species Mus musculus
 Database cross references - Pdcd4
ExoCarta ExoCarta_18569
Vesiclepedia VP_18569
Entrez Gene 18569
UniProt Q61823  
 Pdcd4 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Pdcd4
Molecular Function
    RNA binding GO:0003723 IEA
    protein binding GO:0005515 IPI
Biological Process
    apoptotic process GO:0006915 IEA
    response to hormone GO:0009725 IEA
    BMP signaling pathway GO:0030509 IEA
    BMP signaling pathway GO:0030509 ISO
    positive regulation of smooth muscle cell apoptotic process GO:0034393 ISO
    negative regulation of apoptotic process GO:0043066 IEA
    negative regulation of apoptotic process GO:0043066 ISO
    response to alkaloid GO:0043279 IEA
    negative regulation of JUN kinase activity GO:0043508 ISS
    negative regulation of DNA-templated transcription GO:0045892 ISO
    negative regulation of DNA-templated transcription GO:0045892 ISS
    positive regulation of inflammatory response GO:0050729 IMP
    regulation of protein metabolic process GO:0051246 ISO
    epithelial to mesenchymal transition involved in cardiac fibroblast development GO:0060940 IEA
    epithelial to mesenchymal transition involved in cardiac fibroblast development GO:0060940 ISO
    cellular response to lipopolysaccharide GO:0071222 IMP
    negative regulation of cytokine production involved in inflammatory response GO:1900016 IMP
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 IEA
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 ISO
    negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IEA
    negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 ISO
    negative regulation of myofibroblast differentiation GO:1904761 IEA
    negative regulation of myofibroblast differentiation GO:1904761 ISO
    negative regulation of vascular associated smooth muscle cell differentiation GO:1905064 IEA
    negative regulation of vascular associated smooth muscle cell differentiation GO:1905064 ISO
    positive regulation of vascular associated smooth muscle cell apoptotic process GO:1905461 IEA
    positive regulation of vascular associated smooth muscle cell apoptotic process GO:1905461 ISO
    positive regulation of endothelial cell apoptotic process GO:2000353 IEA
    positive regulation of endothelial cell apoptotic process GO:2000353 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
 Experiment description of studies that identified Pdcd4 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Pdcd4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Foxp3  
Affinity Capture-MS Mus musculus
2 Fancd2  
Affinity Capture-MS Mus musculus
3 Unk  
Affinity Capture-RNA Mus musculus
View the network image/svg+xml
 Pathways in which Pdcd4 is involved
No pathways found





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