Gene description for Per3
Gene name period circadian clock 3
Gene symbol Per3
Other names/aliases 2810049O06Rik
mPer3
Species Mus musculus
 Database cross references - Per3
ExoCarta ExoCarta_18628
Vesiclepedia VP_18628
Entrez Gene 18628
UniProt O70361  
 Per3 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Per3
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IBA
    transcription corepressor binding GO:0001222 IBA
    protein binding GO:0005515 IPI
    kinase binding GO:0019900 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    circadian rhythm GO:0007623 IDA
    circadian regulation of gene expression GO:0032922 IBA
    entrainment of circadian clock by photoperiod GO:0043153 IBA
    regulation of circadian sleep/wake cycle, sleep GO:0045187 IMP
    regulation of circadian sleep/wake cycle, sleep GO:0045187 ISO
    regulation of circadian sleep/wake cycle, sleep GO:0045187 ISS
    protein stabilization GO:0050821 ISO
    protein stabilization GO:0050821 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified Per3 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Per3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cry1  
Affinity Capture-Western Mus musculus
2 Nr1d2  
Co-fractionation Mus musculus
3 Arntl  
Affinity Capture-Western Mus musculus
4 Per1  
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
5 Hlf  
Co-fractionation Mus musculus
6 Cry2  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
7 Csnk1e  
Affinity Capture-Western Rattus norvegicus
8 Clock  
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
9 Per2  
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Per3 is involved
No pathways found





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