Gene description for Abcb1b
Gene name ATP-binding cassette, sub-family B (MDR/TAP), member 1B
Gene symbol Abcb1b
Other names/aliases Abcb1
Mdr1
Mdr1b
Pgy-1
Pgy1
mdr
Species Mus musculus
 Database cross references - Abcb1b
ExoCarta ExoCarta_18669
Vesiclepedia VP_18669
Entrez Gene 18669
UniProt P06795  
 Abcb1b identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Abcb1b
Molecular Function
    ATP binding GO:0005524 IEA
    ATP binding GO:0005524 ISO
    ABC-type xenobiotic transporter activity GO:0008559 IEA
    ABC-type xenobiotic transporter activity GO:0008559 ISO
    efflux transmembrane transporter activity GO:0015562 ISO
    ATP hydrolysis activity GO:0016887 IEA
    ubiquitin protein ligase binding GO:0031625 ISO
    ATPase-coupled transmembrane transporter activity GO:0042626 IBA
    ATPase-coupled transmembrane transporter activity GO:0042626 ISO
    xenobiotic transmembrane transporter activity GO:0042910 IBA
    xenobiotic transmembrane transporter activity GO:0042910 ISO
    carboxylic acid transmembrane transporter activity GO:0046943 ISO
    phosphatidylcholine floppase activity GO:0090554 IBA
    phosphatidylcholine floppase activity GO:0090554 IEA
    phosphatidylcholine floppase activity GO:0090554 ISO
    phosphatidylethanolamine flippase activity GO:0090555 ISO
    ceramide floppase activity GO:0099038 ISO
    floppase activity GO:0140328 ISO
    floppase activity GO:0140328 ISS
Biological Process
    G2/M transition of mitotic cell cycle GO:0000086 ISO
    response to xenobiotic stimulus GO:0009410 ISO
    establishment of endothelial blood-brain barrier GO:0014045 ISO
    phospholipid transport GO:0015914 IEA
    lipid translocation GO:0034204 IEA
    xenobiotic transport GO:0042908 IEA
    phospholipid translocation GO:0045332 IBA
    phospholipid translocation GO:0045332 ISO
    regulation of response to osmotic stress GO:0047484 ISO
    transmembrane transport GO:0055085 IEA
    Sertoli cell barrier remodeling GO:0061843 ISO
    transepithelial transport GO:0070633 ISO
    stem cell proliferation GO:0072089 ISO
    ceramide translocation GO:0099040 IBA
    ceramide translocation GO:0099040 ISO
    export across plasma membrane GO:0140115 ISO
    positive regulation of anion channel activity GO:1901529 ISO
    carboxylic acid transmembrane transport GO:1905039 ISO
    xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961 ISO
    xenobiotic transport across blood-brain barrier GO:1990962 ISO
    regulation of chloride transport GO:2001225 ISO
Subcellular Localization
    Golgi membrane GO:0000139 ISO
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 HDA
    plasma membrane GO:0005886 ISO
    cell surface GO:0009986 ISO
    membrane GO:0016020 ISO
    apical plasma membrane GO:0016324 IBA
    apical plasma membrane GO:0016324 IEA
    apical plasma membrane GO:0016324 ISO
    intercellular canaliculus GO:0046581 IDA
    external side of apical plasma membrane GO:0098591 ISO
 Experiment description of studies that identified Abcb1b in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 214
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 215
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 216
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Abcb1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rps27l  
Co-fractionation Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Abcb1b is involved
No pathways found





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