Gene description for Abcb1a
Gene name	ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Gene symbol	Abcb1a
Other names/aliases	Abcb4 Evi32 Mdr1a Mdr3 P-gp Pgp Pgy-3 Pgy3 mdr-3
Species	Mus musculus
Database cross references - Abcb1a
ExoCarta	ExoCarta_18671
Vesiclepedia	VP_18671
Entrez Gene	18671
UniProt	P21447
Abcb1a identified in sEVs derived from the following tissue/cell type
Faeces	33431899
Faeces	33431899

Gene ontology annotations for Abcb1a

Molecular Function     ATP binding GO:0005524 IEA     ATP binding GO:0005524 ISO     ABC-type xenobiotic transporter activity GO:0008559 IEA     ABC-type xenobiotic transporter activity GO:0008559 ISO     efflux transmembrane transporter activity GO:0015562 IMP     efflux transmembrane transporter activity GO:0015562 ISO     ATP hydrolysis activity GO:0016887 IDA     transmembrane transporter activity GO:0022857 IMP     ubiquitin protein ligase binding GO:0031625 ISO     ATPase-coupled transmembrane transporter activity GO:0042626 EXP     ATPase-coupled transmembrane transporter activity GO:0042626 IBA     ATPase-coupled transmembrane transporter activity GO:0042626 ISO     xenobiotic transmembrane transporter activity GO:0042910 IBA     xenobiotic transmembrane transporter activity GO:0042910 IMP     xenobiotic transmembrane transporter activity GO:0042910 ISO     carboxylic acid transmembrane transporter activity GO:0046943 ISO     phosphatidylcholine floppase activity GO:0090554 IBA     phosphatidylcholine floppase activity GO:0090554 IDA     phosphatidylcholine floppase activity GO:0090554 ISO     phosphatidylethanolamine flippase activity GO:0090555 IDA     phosphatidylethanolamine flippase activity GO:0090555 ISO     ceramide floppase activity GO:0099038 IDA     ceramide floppase activity GO:0099038 ISO     floppase activity GO:0140328 IMP     floppase activity GO:0140328 ISO     floppase activity GO:0140328 ISS Biological Process     G2/M transition of mitotic cell cycle GO:0000086 ISO     response to hypoxia GO:0001666 IEA     placenta development GO:0001890 IEA     female pregnancy GO:0007565 IEA     lactation GO:0007595 IEA     circadian rhythm GO:0007623 IEA     response to xenobiotic stimulus GO:0009410 IEA     hormone transport GO:0009914 IEA     response to progesterone GO:0032570 IEA     response to vitamin A GO:0033189 IEA     response to vitamin D GO:0033280 IEA     response to glucagon GO:0033762 IEA     maintenance of blood-brain barrier GO:0035633 IEA     cellular response to mycotoxin GO:0036146 IEA     daunorubicin transport GO:0043215 IEA     phospholipid translocation GO:0045332 IBA     phospholipid translocation GO:0045332 IDA     phospholipid translocation GO:0045332 ISO     response to cadmium ion GO:0046686 IEA     terpenoid transport GO:0046865 IMP     regulation of response to osmotic stress GO:0047484 ISO     intestinal absorption GO:0050892 IEA     establishment of blood-brain barrier GO:0060856 IEA     transepithelial transport GO:0070633 ISO     cellular response to external biotic stimulus GO:0071217 IEA     cellular response to lipopolysaccharide GO:0071222 IEA     cellular response to antibiotic GO:0071236 IEA     cellular response to alkaloid GO:0071312 IEA     cellular response to tumor necrosis factor GO:0071356 IEA     cellular response to estradiol stimulus GO:0071392 IEA     cellular hyperosmotic salinity response GO:0071475 IEA     cellular response to dexamethasone stimulus GO:0071549 IEA     stem cell proliferation GO:0072089 ISO     response to thyroxine GO:0097068 IEA     response to alcohol GO:0097305 IEA     response to antineoplastic agent GO:0097327 IEA     ceramide translocation GO:0099040 IBA     ceramide translocation GO:0099040 IDA     ceramide translocation GO:0099040 ISO     export across plasma membrane GO:0140115 IMP     export across plasma membrane GO:0140115 ISO     positive regulation of anion channel activity GO:1901529 ISO     protein localization to bicellular tight junction GO:1902396 IEA     response to glycoside GO:1903416 IEA     negative regulation of sensory perception of pain GO:1904057 IEA     cellular response to nonylphenol GO:1904148 IEA     positive regulation of establishment of Sertoli cell barrier GO:1904446 IEA     regulation of intestinal absorption GO:1904478 IEA     carboxylic acid transmembrane transport GO:1905039 ISO     cellular response to borneol GO:1905231 IEA     cellular response to L-glutamate GO:1905232 IEA     response to codeine GO:1905233 IEA     response to quercetin GO:1905235 IEA     response to cyclosporin A GO:1905237 IEA     xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961 IDA     xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961 ISO     xenobiotic transport across blood-brain barrier GO:1990962 IMP     xenobiotic transport across blood-brain barrier GO:1990962 ISO     establishment of blood-retinal barrier GO:1990963 IEA     positive regulation of response to drug GO:2001025 IEA     regulation of chloride transport GO:2001225 ISO Subcellular Localization     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 TAS     cell surface GO:0009986 ISO     membrane GO:0016020 ISO     apical plasma membrane GO:0016324 IBA     apical plasma membrane GO:0016324 IDA     apical plasma membrane GO:0016324 ISO     brush border membrane GO:0031526 IEA     intercellular canaliculus GO:0046581 IDA