Gene description for Phf2
Gene name PHD finger protein 2
Gene symbol Phf2
Other names/aliases GRC5
Species Mus musculus
 Database cross references - Phf2
ExoCarta ExoCarta_18676
Entrez Gene 18676
UniProt Q9WTU0  
 Phf2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Phf2
Molecular Function
    DNA-N1-methyladenine dioxygenase activity GO:0043734 IEA
    C-20 gibberellin 2-beta-dioxygenase activity GO:0052635 IEA
    methylated histone binding GO:0035064 ISO
    C-19 gibberellin 2-beta-dioxygenase activity GO:0052634 IEA
    transcription coactivator activity GO:0003713 ISO
    oxidoreductase activity GO:0016491 IEA
    sulfonate dioxygenase activity GO:0000907 IEA
    iron ion binding GO:0005506 ISO
    metal ion binding GO:0046872 IEA
    2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity GO:0018602 IEA
    histone demethylase activity (H3-K9 specific) GO:0032454 TAS
    zinc ion binding GO:0008270 ISO
    hypophosphite dioxygenase activity GO:0034792 IEA
    procollagen-proline dioxygenase activity GO:0019798 IEA
    dioxygenase activity GO:0051213 IEA
Biological Process
    negative regulation of chromatin silencing at rDNA GO:0061188 ISO
    protein demethylation GO:0006482 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    oxidation-reduction process GO:0055114 IEA
    transcription, DNA-templated GO:0006351 IEA
    histone H3-K9 demethylation GO:0033169 ISO
    chromatin modification GO:0016568 IEA
Subcellular Localization
    kinetochore GO:0000776 IEA
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 ISO
    chromosome, centromeric region GO:0000775 IEA
    chromosome GO:0005694 IEA
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Phf2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Phf2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Phf2 is involved
PathwayEvidenceSource
HDMs demethylate histones IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here