Gene description for Pigr
Gene name polymeric immunoglobulin receptor
Gene symbol Pigr
Other names/aliases -
Species Mus musculus
 Database cross references - Pigr
ExoCarta ExoCarta_18703
Vesiclepedia VP_18703
Entrez Gene 18703
UniProt O70570  
 Pigr identified in sEVs derived from the following tissue/cell type
Faeces 33431899    
Faeces 33431899    
 Gene ontology annotations for Pigr
Molecular Function
    polymeric immunoglobulin binding GO:0001790 IEA
    polymeric immunoglobulin binding GO:0001790 ISO
    polymeric immunoglobulin receptor activity GO:0001792 IEA
    polymeric immunoglobulin receptor activity GO:0001792 ISO
    transmembrane signaling receptor activity GO:0004888 IBA
    epidermal growth factor receptor binding GO:0005154 ISO
Biological Process
    detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 IEA
    detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 ISO
    immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor GO:0002415 IBA
    immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor GO:0002415 ISO
    immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor GO:0002415 ISS
    signal transduction GO:0007165 IBA
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    epidermal growth factor receptor signaling pathway GO:0007173 ISO
    Fc receptor signaling pathway GO:0038093 IEA
    Fc receptor signaling pathway GO:0038093 ISO
    receptor clustering GO:0043113 IEA
    receptor clustering GO:0043113 ISO
Subcellular Localization
    extracellular space GO:0005615 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    receptor complex GO:0043235 ISO
    recycling endosome membrane GO:0055038 ISO
    secretory IgA immunoglobulin complex GO:0071751 ISO
    secretory IgA immunoglobulin complex GO:0071751 ISS
 Experiment description of studies that identified Pigr in sEVs
1
Experiment ID 303
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
2
Experiment ID 304
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
 Protein-protein interactions for Pigr
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Eed  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Pigr is involved
PathwayEvidenceSource
Immune System IEA Reactome
Innate Immune System IEA Reactome
Neutrophil degranulation IEA Reactome





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