Gene description for Serpine1
Gene name serine (or cysteine) peptidase inhibitor, clade E, member 1
Gene symbol Serpine1
Other names/aliases PAI-1
Species Mus musculus
 Database cross references - Serpine1
ExoCarta ExoCarta_18787
Entrez Gene 18787
 Serpine1 identified in exosomes derived from the following tissue/cell type
Mov neuroglial cells 15210972    
 Gene ontology annotations for Serpine1
Molecular Function
    peptidase inhibitor activity GO:0030414 IEA
    protein binding GO:0005515 IPI
    protease binding GO:0002020 ISO
    serine-type endopeptidase inhibitor activity GO:0004867 ISO
    receptor binding GO:0005102 ISO
Biological Process
    defense response to Gram-negative bacterium GO:0050829 ISO
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 ISO
    negative regulation of plasminogen activation GO:0010757 ISO
    wound healing GO:0042060 ISO
    positive regulation of interleukin-8 production GO:0032757 ISO
    positive regulation of gene expression GO:0010628 ISO
    positive regulation of angiogenesis GO:0045766 ISO
    positive regulation of monocyte chemotaxis GO:0090026 ISO
    cellular response to drug GO:0035690 ISO
    negative regulation of vascular wound healing GO:0061044 ISO
    positive regulation of leukotriene production involved in inflammatory response GO:0035491 ISO
    negative regulation of smooth muscle cell migration GO:0014912 ISO
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
    negative regulation of smooth muscle cell-matrix adhesion GO:2000098 ISO
    positive regulation of keratinocyte migration GO:0051549 ISO
    negative regulation of fibrinolysis GO:0051918 ISO
    positive regulation of fibroblast proliferation GO:0048146 ISO
    negative regulation of endothelial cell apoptotic process GO:2000352 ISO
    positive regulation of receptor-mediated endocytosis GO:0048260 ISO
    regulation of receptor activity GO:0010469 ISO
    negative regulation of gene expression GO:0010629 ISO
    positive regulation of coagulation GO:0050820 ISO
    positive regulation of inflammatory response GO:0050729 ISO
    positive regulation of calcium ion import GO:0090280 ISO
    regulation of angiogenesis GO:0045765 IDA
    cellular response to lipopolysaccharide GO:0071222 ISO
    positive regulation of blood coagulation GO:0030194 ISO
    negative regulation of peptidase activity GO:0010466 IEA
    cellular response to interleukin-1 GO:0071347 ISO
    negative regulation of cell adhesion mediated by integrin GO:0033629 ISO
    negative regulation of cell migration GO:0030336 ISO
    female gonad development GO:0008585 ISO
    negative regulation of endopeptidase activity GO:0010951 ISO
    regulation of cell proliferation GO:0042127 IGI
Subcellular Localization
    chromaffin granule GO:0042583 ISO
    extracellular matrix GO:0031012 ISO
    extracellular exosome GO:0070062 ISO
    extracellular region GO:0005576 ISO
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Serpine1 in exosomes
Experiment ID 39
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Serpine1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Serpine1 is involved
No pathways found

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