Gene description for Plau
Gene name plasminogen activator, urokinase
Gene symbol Plau
Other names/aliases u-PA
uPA
Species Mus musculus
 Database cross references - Plau
ExoCarta ExoCarta_18792
Vesiclepedia VP_18792
Entrez Gene 18792
UniProt P06869  
 Plau identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Plau
Molecular Function
    serine-type endopeptidase activity GO:0004252 IBA
    serine-type endopeptidase activity GO:0004252 IEA
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 ISO
Biological Process
    angiogenesis GO:0001525 ISO
    response to hypoxia GO:0001666 IMP
    positive regulation of cell population proliferation GO:0008284 ISO
    regulation of signaling receptor activity GO:0010469 ISO
    regulation of plasminogen activation GO:0010755 NAS
    negative regulation of plasminogen activation GO:0010757 NAS
    smooth muscle cell migration GO:0014909 IMP
    regulation of smooth muscle cell migration GO:0014910 IEA
    regulation of smooth muscle cell migration GO:0014910 ISO
    positive regulation of smooth muscle cell migration GO:0014911 ISO
    regulation of cell adhesion GO:0030155 ISO
    positive regulation of cell migration GO:0030335 ISO
    plasminogen activation GO:0031639 IBA
    plasminogen activation GO:0031639 IEA
    plasminogen activation GO:0031639 ISO
    regulation of cell adhesion mediated by integrin GO:0033628 IBA
    regulation of cell adhesion mediated by integrin GO:0033628 IEA
    regulation of cell adhesion mediated by integrin GO:0033628 ISO
    urokinase plasminogen activator signaling pathway GO:0038195 NAS
    regulation of cell population proliferation GO:0042127 IGI
    fibrinolysis GO:0042730 IBA
    fibrinolysis GO:0042730 IMP
    skeletal muscle tissue regeneration GO:0043403 ISO
    regulation of fibrinolysis GO:0051917 NAS
    negative regulation of fibrinolysis GO:0051918 NAS
    regulation of smooth muscle cell-matrix adhesion GO:2000097 IEA
    regulation of smooth muscle cell-matrix adhesion GO:2000097 ISO
    regulation of hepatocyte proliferation GO:2000345 ISO
    positive regulation of reactive oxygen species metabolic process GO:2000379 ISO
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISS
    external side of plasma membrane GO:0009897 NAS
    cell surface GO:0009986 ISO
    serine protease inhibitor complex GO:0097180 ISO
    protein complex involved in cell-matrix adhesion GO:0098637 ISO
    serine-type endopeptidase complex GO:1905370 IPI
    serine-type endopeptidase complex GO:1905370 ISO
 Experiment description of studies that identified Plau in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Plau
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Apc  
Phenotypic Suppression Mus musculus
View the network image/svg+xml
 Pathways in which Plau is involved
PathwayEvidenceSource
Dissolution of Fibrin Clot IEA Reactome
Hemostasis IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
Neutrophil degranulation IEA Reactome





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