Gene description for Plau
Gene name plasminogen activator, urokinase
Gene symbol Plau
Other names/aliases u-PA
uPA
Species Mus musculus
 Database cross references - Plau
ExoCarta ExoCarta_18792
Vesiclepedia VP_18792
Entrez Gene 18792
UniProt P06869  
 Plau identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Plau
Molecular Function
    serine-type endopeptidase activity GO:0004252 IBA
    hydrolase activity GO:0016787 IEA
    serine-type peptidase activity GO:0008236 IEA
    peptidase activity GO:0008233 ISO
Biological Process
    fibrinolysis GO:0042730 IMP
    positive regulation of ovulation GO:0060279 ISO
    regulation of cell adhesion mediated by integrin GO:0033628 ISO
    regulation of hepatocyte proliferation GO:2000345 ISO
    positive regulation of cell proliferation GO:0008284 ISO
    response to hypoxia GO:0001666 IMP
    regulation of smooth muscle cell-matrix adhesion GO:2000097 ISO
    neuron death GO:0070997 ISO
    proteolysis GO:0006508 ISO
    regulation of smooth muscle cell migration GO:0014910 ISO
    regulation of cell proliferation GO:0042127 IGI
    skeletal muscle tissue regeneration GO:0043403 ISO
    smooth muscle cell migration GO:0014909 IMP
    angiogenesis GO:0001525 ISO
    positive regulation of smooth muscle cell migration GO:0014911 ISO
    positive regulation of reactive oxygen species metabolic process GO:2000379 ISO
    wound healing GO:0042060 ISO
    regulation of receptor activity GO:0010469 ISO
    plasminogen activation GO:0031639 IBA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 ISO
    cell surface GO:0009986 ISO
    extracellular region GO:0005576 IEA
    focal adhesion GO:0005925 ISO
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Plau in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Plau
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Plau is involved
PathwayEvidenceSource
Dissolution of Fibrin Clot IEA Reactome





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