Gene description for Plaur
Gene name plasminogen activator, urokinase receptor
Gene symbol Plaur
Other names/aliases Cd87
u-PAR
uPAR
Species Mus musculus
 Database cross references - Plaur
ExoCarta ExoCarta_18793
Vesiclepedia VP_18793
Entrez Gene 18793
UniProt P35456  
 Plaur identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Plaur
Molecular Function
    signaling receptor binding GO:0005102 IEA
    signaling receptor binding GO:0005102 ISO
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IEA
    enzyme binding GO:0019899 ISO
    protein domain specific binding GO:0019904 IEA
    protein domain specific binding GO:0019904 ISO
Biological Process
    positive regulation of protein phosphorylation GO:0001934 ISO
    regulation of plasminogen activation GO:0010755 NAS
    regulation of cell adhesion GO:0030155 ISO
    positive regulation of homotypic cell-cell adhesion GO:0034112 IEA
    positive regulation of homotypic cell-cell adhesion GO:0034112 ISO
    urokinase plasminogen activator signaling pathway GO:0038195 NAS
    negative regulation of apoptotic process GO:0043066 ISO
    positive regulation of DNA binding GO:0043388 ISO
    positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 IEA
    positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 ISO
    mesenchymal cell differentiation GO:0048762 ISO
    regulation of fibrinolysis GO:0051917 NAS
    epithelial cell differentiation involved in prostate gland development GO:0060742 ISO
    positive regulation of release of cytochrome c from mitochondria GO:0090200 IEA
    positive regulation of release of cytochrome c from mitochondria GO:0090200 ISO
    negative regulation of cysteine-type endopeptidase activity GO:2000117 ISO
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IEA
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    external side of plasma membrane GO:0009897 NAS
    cell surface GO:0009986 ISO
    protein complex involved in cell-matrix adhesion GO:0098637 ISO
    serine-type endopeptidase complex GO:1905370 IPI
    serine-type endopeptidase complex GO:1905370 ISO
 Experiment description of studies that identified Plaur in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Plaur
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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