Gene description for Plod1
Gene name procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
Gene symbol Plod1
Other names/aliases 2410042F05Rik
Species Mus musculus
 Database cross references - Plod1
ExoCarta ExoCarta_18822
Entrez Gene 18822
UniProt Q9R0E2  
 Plod1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Plod1
Molecular Function
    peptide binding GO:0042277 ISO
    metal ion binding GO:0046872 IEA
    ferrous iron binding GO:0008198 ISO
    iron ion binding GO:0005506 IEA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0016706 IEA
    L-ascorbic acid binding GO:0031418 ISO
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 IEA
    dioxygenase activity GO:0051213 IEA
    oxidoreductase activity GO:0016491 IEA
    procollagen-lysine 5-dioxygenase activity GO:0008475 ISO
Biological Process
    peptidyl-lysine hydroxylation GO:0017185 ISO
    oxidation-reduction process GO:0055114 ISO
    epidermis development GO:0008544 ISO
Subcellular Localization
    endoplasmic reticulum GO:0005783 IEA
    membrane GO:0016020 IEA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Plod1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Plod1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Plod1 is involved
Collagen biosynthesis and modifying enzymes IEA Reactome

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