Gene description for Pltp
Gene name phospholipid transfer protein
Gene symbol Pltp
Other names/aliases Bpife
OD107
Species Mus musculus
 Database cross references - Pltp
ExoCarta ExoCarta_18830
Vesiclepedia VP_18830
Entrez Gene 18830
UniProt P55065  
 Pltp identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
Mast cells 17486113    
 Gene ontology annotations for Pltp
Molecular Function
    high-density lipoprotein particle binding GO:0008035 ISO
    high-density lipoprotein particle binding GO:0008035 ISS
    phosphatidylethanolamine binding GO:0008429 IEA
    phosphatidylethanolamine binding GO:0008429 ISO
    phosphatidylinositol transfer activity GO:0008526 IMP
    diacylglycerol binding GO:0019992 IEA
    diacylglycerol binding GO:0019992 ISO
    low-density lipoprotein particle binding GO:0030169 ISO
    low-density lipoprotein particle binding GO:0030169 ISS
    phosphatidylcholine binding GO:0031210 IEA
    phosphatidylcholine binding GO:0031210 ISO
    very-low-density lipoprotein particle binding GO:0034189 ISO
    very-low-density lipoprotein particle binding GO:0034189 ISS
    phosphatidic acid binding GO:0070300 IEA
    phosphatidic acid binding GO:0070300 ISO
    ceramide binding GO:0097001 IEA
    ceramide binding GO:0097001 ISO
    phospholipid transfer activity GO:0120014 IDA
    phospholipid transfer activity GO:0120014 ISO
    ceramide transfer activity GO:0120017 IBA
    phosphatidylcholine transfer activity GO:0120019 IMP
    phosphatidylcholine transfer activity GO:0120019 ISO
    cholesterol transfer activity GO:0120020 IMP
    diacylglyceride transfer activity GO:0140337 IEA
    diacylglyceride transfer activity GO:0140337 ISO
    sphingomyelin transfer activity GO:0140338 IMP
    sphingomyelin transfer activity GO:0140338 ISO
    phosphatidylglycerol transfer activity GO:0140339 IEA
    phosphatidylglycerol transfer activity GO:0140339 ISO
    cerebroside transfer activity GO:0140340 IEA
    cerebroside transfer activity GO:0140340 ISO
    phosphatidylglycerol binding GO:1901611 IEA
    phosphatidylglycerol binding GO:1901611 ISO
    phosphatidylethanolamine transfer activity GO:1904121 IBA
    phosphatidylethanolamine transfer activity GO:1904121 IMP
    phosphatidylethanolamine transfer activity GO:1904121 ISO
    phosphatidic acid transfer activity GO:1990050 IBA
    phosphatidic acid transfer activity GO:1990050 IEA
    phosphatidic acid transfer activity GO:1990050 ISO
Biological Process
    lipid transport GO:0006869 ISO
    vitamin E biosynthetic process GO:0010189 IMP
    positive regulation of cholesterol efflux GO:0010875 IEA
    positive regulation of cholesterol efflux GO:0010875 ISO
    phospholipid transport GO:0015914 IBA
    phospholipid transport GO:0015914 IEA
    phospholipid transport GO:0015914 ISO
    sterol transport GO:0015918 IEA
    flagellated sperm motility GO:0030317 IMP
    high-density lipoprotein particle remodeling GO:0034375 IBA
    high-density lipoprotein particle remodeling GO:0034375 ISO
    high-density lipoprotein particle remodeling GO:0034375 ISS
    ceramide transport GO:0035627 IBA
    ceramide transport GO:0035627 IEA
    ceramide transport GO:0035627 ISO
    glycolipid transport GO:0046836 IEA
    glycolipid transport GO:0046836 ISO
    intermembrane lipid transfer GO:0120009 IEA
Subcellular Localization
    extracellular region GO:0005576 ISO
    extracellular region GO:0005576 ISS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    high-density lipoprotein particle GO:0034364 IEA
    high-density lipoprotein particle GO:0034364 ISO
 Experiment description of studies that identified Pltp in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Pltp
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
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