Gene description for Pltp
Gene name phospholipid transfer protein
Gene symbol Pltp
Other names/aliases Bpife
OD107
Species Mus musculus
 Database cross references - Pltp
ExoCarta ExoCarta_18830
Entrez Gene 18830
UniProt P55065  
 Pltp identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Mast cells 17486113    
 Gene ontology annotations for Pltp
Molecular Function
    lipid binding GO:0008289 IEA
Biological Process
    lipid transport GO:0006869 IEA
    sperm motility GO:0030317 IMP
    high-density lipoprotein particle remodeling GO:0034375 ISO
    transport GO:0006810 IEA
    positive regulation of cholesterol efflux GO:0010875 ISO
    lipid metabolic process GO:0006629 IEA
    vitamin E biosynthetic process GO:0010189 IMP
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Pltp in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Pltp
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pltp is involved
PathwayEvidenceSource
HDL-mediated lipid transport IEA Reactome





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