Gene description for Pnliprp2
Gene name pancreatic lipase-related protein 2
Gene symbol Pnliprp2
Other names/aliases PLRP2
Species Mus musculus
 Database cross references - Pnliprp2
ExoCarta ExoCarta_18947
Vesiclepedia VP_18947
Entrez Gene 18947
 Pnliprp2 identified in sEVs derived from the following tissue/cell type
Faeces 33431899    
Faeces 33431899    
 Gene ontology annotations for Pnliprp2
Molecular Function
    lipoprotein lipase activity GO:0004465 IBA
    phospholipase activity GO:0004620 ISO
    phospholipase activity GO:0004620 ISS
    triacylglycerol lipase activity GO:0004806 IDA
    triacylglycerol lipase activity GO:0004806 ISO
    calcium ion binding GO:0005509 ISO
    calcium ion binding GO:0005509 ISS
    phospholipase A1 activity GO:0008970 IBA
    lipase activity GO:0016298 ISO
    monoacylglycerol lipase activity GO:0047372 ISO
    monoacylglycerol lipase activity GO:0047372 ISS
    galactolipase activity GO:0047714 IBA
    galactolipase activity GO:0047714 ISO
    galactolipase activity GO:0047714 ISS
Biological Process
    fatty acid biosynthetic process GO:0006633 IBA
    phospholipid metabolic process GO:0006644 ISO
    phospholipid metabolic process GO:0006644 ISS
    cellular defense response GO:0006968 IMP
    phospholipid catabolic process GO:0009395 IBA
    phospholipid catabolic process GO:0009395 ISO
    phospholipid catabolic process GO:0009395 ISS
    response to bacterium GO:0009617 IEP
    galactolipid catabolic process GO:0019376 ISO
    galactolipid catabolic process GO:0019376 ISS
    triglyceride catabolic process GO:0019433 IBA
    triglyceride catabolic process GO:0019433 IEA
    triglyceride catabolic process GO:0019433 ISO
    triglyceride catabolic process GO:0019433 ISS
    high-density lipoprotein particle remodeling GO:0034375 IBA
    phosphatidylcholine catabolic process GO:0034638 ISO
    phosphatidylcholine catabolic process GO:0034638 ISS
    cholesterol homeostasis GO:0042632 IBA
    intestinal lipid catabolic process GO:0044258 IMP
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISS
    zymogen granule membrane GO:0042589 IEA
    zymogen granule membrane GO:0042589 ISO
    neuron projection GO:0043005 ISO
    neuron projection GO:0043005 ISS
 Experiment description of studies that identified Pnliprp2 in sEVs
1
Experiment ID 303
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
2
Experiment ID 304
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
 Protein-protein interactions for Pnliprp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pnliprp2 is involved
PathwayEvidenceSource
Digestion IEA Reactome
Digestion and absorption IEA Reactome
Digestion of dietary lipid IEA Reactome





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