Gene description for Pou4f1
Gene name POU domain, class 4, transcription factor 1
Gene symbol Pou4f1
Other names/aliases Brn-3
Brn-3.0
Brn3
Brn3.0
Brn3a
E130119J07Rik
Species Mus musculus
 Database cross references - Pou4f1
ExoCarta ExoCarta_18996
Entrez Gene 18996
UniProt P17208  
 Pou4f1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Pou4f1
Molecular Function
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0003705 IDA
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IDA
    sequence-specific DNA binding transcription factor activity GO:0003700 IMP
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001205 IMP
    sequence-specific DNA binding GO:0043565 IEA
Biological Process
    mesoderm development GO:0007498 IMP
    regulation of neurogenesis GO:0050767 IMP
    habenula development GO:0021986 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    transcription, DNA-templated GO:0006351 IEA
    neuron fate specification GO:0048665 IMP
    positive regulation of apoptotic process GO:0043065 IGI
    neuron differentiation GO:0030182 IMP
    sensory system development GO:0048880 IMP
    peripheral nervous system neuron development GO:0048935 IMP
    transcription from RNA polymerase II promoter GO:0006366 IMP
    proprioception involved in equilibrioception GO:0051355 IMP
    regulation of transcription, DNA-templated GO:0006355 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    cell migration in hindbrain GO:0021535 IMP
    suckling behavior GO:0001967 IMP
    peripheral nervous system neuron differentiation GO:0048934 IMP
    innervation GO:0060384 IMP
    negative regulation of neuron apoptotic process GO:0043524 ISO
    nervous system development GO:0007399 IDA
    trigeminal nerve development GO:0021559 IMP
    central nervous system neuron differentiation GO:0021953 IMP
    ventricular compact myocardium morphogenesis GO:0003223 IMP
    regulation of transcription from RNA polymerase II promoter GO:0006357 IC
    multicellular organismal development GO:0007275 IEA
Subcellular Localization
    nuclear chromatin GO:0000790 IDA
    nucleus GO:0005634 IDA
    neuron projection GO:0043005 IDA
 Experiment description of studies that identified Pou4f1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Pou4f1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pou4f1 is involved
No pathways found





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