Gene description for Pparg
Gene name peroxisome proliferator activated receptor gamma
Gene symbol Pparg
Other names/aliases Nr1c3
PPAR-gamma
PPAR-gamma2
PPARgamma
PPARgamma2
Species Mus musculus
 Database cross references - Pparg
ExoCarta ExoCarta_19016
Vesiclepedia VP_19016
Entrez Gene 19016
UniProt P37238  
 Pparg identified in exosomes derived from the following tissue/cell type
Lung cancer cells 36270983    
Lung epithelial cells 36270983    
 Gene ontology annotations for Pparg
Molecular Function
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 ISO
    retinoid X receptor binding GO:0046965 ISO
    RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001228 IDA
    ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 ISO
    protein phosphatase binding GO:0019903 ISO
    chromatin binding GO:0003682 IDA
    ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0004879 TAS
    transcription regulatory region DNA binding GO:0044212 ISO
    activating transcription factor binding GO:0033613 ISO
    zinc ion binding GO:0008270 IEA
    RNA polymerase II regulatory region DNA binding GO:0001012 IDA
    sequence-specific DNA binding GO:0043565 ISO
    DNA binding GO:0003677 ISO
    core promoter sequence-specific DNA binding GO:0001046 IDA
    drug binding GO:0008144 ISO
    metal ion binding GO:0046872 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 ISO
    WW domain binding GO:0050699 ISO
    transcription factor binding GO:0008134 ISO
    estrogen receptor binding GO:0030331 ISO
    arachidonic acid binding GO:0050544 IDA
    steroid hormone receptor activity GO:0003707 IEA
    alpha-actinin binding GO:0051393 ISO
Biological Process
    transcription from RNA polymerase II promoter GO:0006366 IDA
    negative regulation of telomerase activity GO:0051974 ISO
    intracellular receptor signaling pathway GO:0030522 TAS
    cellular response to lithium ion GO:0071285 IDA
    negative regulation of cell proliferation GO:0008285 ISO
    regulation of transcription, DNA-templated GO:0006355 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    peroxisome proliferator activated receptor signaling pathway GO:0035357 ISO
    rhythmic process GO:0048511 IEA
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 ISO
    negative regulation of cytokine production GO:0001818 IMP
    positive regulation of oligodendrocyte differentiation GO:0048714 ISO
    negative regulation of receptor biosynthetic process GO:0010871 ISO
    response to low-density lipoprotein particle GO:0055098 ISO
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    diet induced thermogenesis GO:0002024 IMP
    brown fat cell differentiation GO:0050873 IDA
    epithelial cell differentiation GO:0030855 IGI
    cell maturation GO:0048469 ISO
    response to lipid GO:0033993 IDA
    transcription, DNA-templated GO:0006351 IEA
    cellular response to insulin stimulus GO:0032869 ISO
    negative regulation of acute inflammatory response GO:0002674 ISO
    regulation of transcription involved in cell fate commitment GO:0060850 IMP
    white fat cell differentiation GO:0050872 IDA
    negative regulation of smooth muscle cell proliferation GO:0048662 ISO
    inflammatory response GO:0006954 TAS
    negative regulation of peptide hormone secretion GO:0090278 IMP
    steroid hormone mediated signaling pathway GO:0043401 IEA
    monocyte differentiation GO:0030224 ISO
    low-density lipoprotein particle receptor biosynthetic process GO:0045713 ISO
    positive regulation of fatty acid oxidation GO:0046321 ISO
    regulation of lipid metabolic process GO:0019216 ISO
    glucose homeostasis GO:0042593 ISO
    positive regulation of phagocytosis, engulfment GO:0060100 ISO
    negative regulation of cholesterol storage GO:0010887 ISO
    placenta development GO:0001890 IMP
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 ISO
    regulation of circadian rhythm GO:0042752 IMP
    regulation of blood pressure GO:0008217 ISO
    lipoprotein transport GO:0042953 ISO
    negative regulation of sequestering of triglyceride GO:0010891 ISO
    response to retinoic acid GO:0032526 ISO
    cell fate commitment GO:0045165 IMP
    negative regulation of cellular response to insulin stimulus GO:1900077 IMP
    positive regulation of fat cell differentiation GO:0045600 IMP
    response to food GO:0032094 IDA
    response to light stimulus GO:0009416 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    fat cell differentiation GO:0045444 IMP
    response to dietary excess GO:0002021 IDA
    regulation of fat cell differentiation GO:0045598 ISO
    fatty acid oxidation GO:0019395 ISO
    regulation of gene expression GO:0010468 IMP
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    negative regulation of interferon-gamma-mediated signaling pathway GO:0060336 ISO
    cellular response to organic cyclic compound GO:0071407 IDA
    negative regulation of collagen biosynthetic process GO:0032966 ISO
    negative regulation of cell growth GO:0030308 ISO
    signal transduction GO:0007165 ISO
    positive regulation of apoptotic process GO:0043065 ISO
    negative regulation of macrophage derived foam cell differentiation GO:0010745 ISO
    long-chain fatty acid transport GO:0015909 IMP
    negative regulation of pancreatic stellate cell proliferation GO:2000230 ISO
    negative regulation of transcription, DNA-templated GO:0045892 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 ISO
    RNA polymerase II transcription factor complex GO:0090575 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Pparg in exosomes
1
Experiment ID 502
MISEV standards
EM
EV Biophysical techniques
Tsg101|Cd81
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36270983    
Organism Mus musculus
Experiment description NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer
Authors Rao X, Zhou X, Wang G, Jie X, Xing B, Xu Y, Chen Y, Li J, Zhu K, Wu Z, Wu G, Wu C, Zhou R.
Journal name Cell Death Dis
Publication year 2022
Sample Lung cancer cells
Sample name Small cell lung cancer (SCLC)
Isolation/purification methods Centrifugation
Exosome Isolation Reagent
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
2
Experiment ID 503
MISEV standards
EV Biophysical techniques
Tsg101|Cd81
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36270983    
Organism Mus musculus
Experiment description NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer
Authors Rao X, Zhou X, Wang G, Jie X, Xing B, Xu Y, Chen Y, Li J, Zhu K, Wu Z, Wu G, Wu C, Zhou R.
Journal name Cell Death Dis
Publication year 2022
Sample Lung epithelial cells
Sample name Normal lung epithelium
Isolation/purification methods Centrifugation
Exosome Isolation Reagent
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
 Protein-protein interactions for Pparg
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RXRA 6256
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
2 GADD45A  
Affinity Capture-Western Homo sapiens
3 Dut  
Reconstituted Complex Rattus norvegicus
View the network image/svg+xml
 Pathways in which Pparg is involved
No pathways found





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