Gene description for Ctsa
Gene name cathepsin A
Gene symbol Ctsa
Other names/aliases AU019505
PPCA
Ppgb
Species Mus musculus
 Database cross references - Ctsa
ExoCarta ExoCarta_19025
Entrez Gene 19025
UniProt P16675  
 Ctsa identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Ctsa
Molecular Function
    peptidase activity GO:0008233 IEA
    protein binding GO:0005515 IPI
    serine-type carboxypeptidase activity GO:0004185 IEA
    hydrolase activity GO:0016787 IEA
    carboxypeptidase activity GO:0004180 IEA
Biological Process
    proteolysis GO:0006508 IEA
Subcellular Localization
    lysosome GO:0005764 IEA
    membrane GO:0016020 ISO
    nucleoplasm GO:0005654 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    mitochondrion GO:0005739 IDA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Ctsa in exosomes
1
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ctsa
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ctsa is involved
PathwayEvidenceSource
Glycosphingolipid metabolism IEA Reactome
Sialic acid metabolism IEA Reactome





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