Gene description for Srgn
Gene name serglycin
Gene symbol Srgn
Other names/aliases Prg
Prg1
Sgc
Species Mus musculus
 Database cross references - Srgn
ExoCarta ExoCarta_19073
Vesiclepedia VP_19073
Entrez Gene 19073
UniProt P13609  
 Srgn identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Srgn
Molecular Function
    protein binding GO:0005515 IPI
    collagen binding GO:0005518 ISO
Biological Process
    negative regulation of cytokine production GO:0001818 IMP
    apoptotic process GO:0006915 IEA
    protein processing GO:0016485 IDA
    negative regulation of bone mineralization GO:0030502 IBA
    negative regulation of bone mineralization GO:0030502 ISO
    negative regulation of bone mineralization GO:0030502 ISS
    biomineral tissue development GO:0031214 IEA
    secretory granule organization GO:0033363 IBA
    mast cell secretory granule organization GO:0033364 IMP
    T cell secretory granule organization GO:0033371 IMP
    maintenance of protease location in mast cell secretory granule GO:0033373 IMP
    maintenance of granzyme B location in T cell secretory granule GO:0033382 IMP
    granzyme-mediated programmed cell death signaling pathway GO:0140507 ISS
Subcellular Localization
    Golgi membrane GO:0000139 ISO
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISS
    Golgi apparatus GO:0005794 ISO
    Golgi apparatus GO:0005794 ISS
    secretory granule GO:0030141 IBA
    zymogen granule GO:0042588 ISO
    mast cell granule GO:0042629 IDA
    cytolytic granule GO:0044194 IEA
 Experiment description of studies that identified Srgn in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Srgn
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ccnb1ip1  
Two-hybrid Mus musculus
View the network image/svg+xml



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