Gene description for Srgn
Gene name serglycin
Gene symbol Srgn
Other names/aliases Prg
Prg1
Sgc
Species Mus musculus
 Database cross references - Srgn
ExoCarta ExoCarta_19073
Entrez Gene 19073
UniProt P13609  
 Srgn identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Srgn
Molecular Function
    protein binding GO:0005515 IPI
    collagen binding GO:0005518 ISO
Biological Process
    maintenance of protease location in mast cell secretory granule GO:0033373 IMP
    apoptotic process GO:0006915 IEA
    mast cell secretory granule organization GO:0033364 IMP
    maintenance of granzyme B location in T cell secretory granule GO:0033382 IMP
    T cell secretory granule organization GO:0033371 IMP
    negative regulation of cytokine secretion GO:0050710 IMP
    protein processing GO:0016485 IDA
    biomineral tissue development GO:0031214 IEA
Subcellular Localization
    mast cell granule GO:0042629 IDA
    Golgi membrane GO:0000139 ISO
    Golgi apparatus GO:0005794 IEA
    zymogen granule GO:0042588 ISO
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified Srgn in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Srgn
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Srgn is involved
PathwayEvidenceSource
Platelet degranulation IEA Reactome





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