Gene description for Srgn
Gene name serglycin
Gene symbol Srgn
Other names/aliases Prg
Species Mus musculus
 Database cross references - Srgn
ExoCarta ExoCarta_19073
Entrez Gene 19073
UniProt P13609  
 Srgn identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Srgn
Molecular Function
    protein binding GO:0005515 IPI
    collagen binding GO:0005518 ISO
Biological Process
    maintenance of protease location in mast cell secretory granule GO:0033373 IMP
    apoptotic process GO:0006915 IEA
    mast cell secretory granule organization GO:0033364 IMP
    maintenance of granzyme B location in T cell secretory granule GO:0033382 IMP
    T cell secretory granule organization GO:0033371 IMP
    negative regulation of cytokine secretion GO:0050710 IMP
    protein processing GO:0016485 IDA
    biomineral tissue development GO:0031214 IEA
Subcellular Localization
    mast cell granule GO:0042629 IDA
    Golgi membrane GO:0000139 ISO
    Golgi apparatus GO:0005794 IEA
    zymogen granule GO:0042588 ISO
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified Srgn in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Srgn
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Srgn is involved
Platelet degranulation IEA Reactome

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