Gene description for Tgoln2
Gene name trans-golgi network protein 2
Gene symbol Tgoln2
Other names/aliases Tgn38
Tgoln1
Ttgn1
Species Rattus norvegicus
 Database cross references - Tgoln2
ExoCarta ExoCarta_192152
Vesiclepedia VP_192152
Entrez Gene 192152
UniProt P19814  
 Tgoln2 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Tgoln2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    Golgi to endosome transport GO:0006895 TAS
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    endosome GO:0005768 IBA
    endosome GO:0005768 ISO
    endosome GO:0005768 TAS
    Golgi apparatus GO:0005794 ISO
    trans-Golgi network GO:0005802 IBA
    trans-Golgi network GO:0005802 IDA
    trans-Golgi network GO:0005802 ISO
    cytosol GO:0005829 IEA
    membrane GO:0016020 IEA
    trans-Golgi network transport vesicle GO:0030140 IBA
    glutamatergic synapse GO:0098978 IDA
    postsynaptic Golgi apparatus GO:0150051 IDA
 Experiment description of studies that identified Tgoln2 in sEVs
1
Experiment ID 92
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Tgoln2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ppp1r9a  
Far Western Rattus norvegicus
Two-hybrid Rattus norvegicus
Reconstituted Complex Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
2 STXBP5L  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here