Gene description for Unc13d
Gene name unc-13 homolog D (C. elegans)
Gene symbol Unc13d
Other names/aliases Munc13-4
Unc13h4
Species Rattus norvegicus
 Database cross references - Unc13d
ExoCarta ExoCarta_192177
Entrez Gene 192177
UniProt Q9R189  
 Unc13d identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Unc13d
Molecular Function
    molecular_function GO:0003674 ND
    Rab GTPase binding GO:0017137 ISO
Biological Process
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISO
    regulation of mast cell degranulation GO:0043304 ISO
    natural killer cell degranulation GO:0043320 ISO
    secretion GO:0046903 IEP
    exocytosis GO:0006887 IEA
    positive regulation of exocytosis GO:0045921 ISO
    positive regulation of regulated secretory pathway GO:1903307 ISO
    phagocytosis GO:0006909 ISO
    germinal center formation GO:0002467 ISO
    granuloma formation GO:0002432 ISO
    defense response to virus GO:0051607 ISO
Subcellular Localization
    membrane GO:0016020 IEA
    Weibel-Palade body GO:0033093 ISO
    lysosome GO:0005764 ISO
    exocytic vesicle GO:0070382 ISO
    late endosome GO:0005770 IEA
    recycling endosome GO:0055037 IEA
    cellular_component GO:0005575 ND
    cell GO:0005623 ISO
 Experiment description of studies that identified Unc13d in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Unc13d
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Unc13d is involved
No pathways found





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