Gene description for Ubb
Gene name ubiquitin B
Gene symbol Ubb
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ubb
ExoCarta ExoCarta_192255
Entrez Gene 192255
UniProt P0CG51  
 Ubb identified in exosomes derived from the following tissue/cell type
Cortical neurones 16446100    
Hepatocytes 19367702    
Urine 20535238    
 Gene ontology annotations for Ubb
Biological Process
    adipose tissue development GO:0060612 ISO
    energy homeostasis GO:0097009 ISO
    fat pad development GO:0060613 ISO
    female gonad development GO:0008585 ISO
    hypothalamus gonadotrophin-releasing hormone neuron development GO:0021888 ISO
    mitochondrion transport along microtubule GO:0047497 ISO
    ubiquitin homeostasis GO:0010992 ISO
    regulation of proteasomal protein catabolic process GO:0061136 ISO
    male gonad development GO:0008584 ISO
    neuron projection morphogenesis GO:0048812 ISO
    seminiferous tubule development GO:0072520 ISO
    male meiosis I GO:0007141 ISO
    regulation of neuron death GO:1901214 ISO
    positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902255 ISO
    regulation of mitochondrial membrane potential GO:0051881 ISO
    female meiosis I GO:0007144 ISO
Subcellular Localization
    nucleus GO:0005634 IEA
    mitochondrion GO:0005739 ISO
    cytoplasm GO:0005737 IEA
    neuron projection GO:0043005 ISO
    cell GO:0005623 ISO
    extracellular exosome GO:0070062 ISO
    neuronal cell body GO:0043025 ISO
 Experiment description of studies that identified Ubb in exosomes
1
Experiment ID 30
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 16446100    
Organism Rattus norvegicus
Experiment description Exosomes are released by cultured cortical neurones.
Authors Faure J, Lachenal G, Court M, Hirrlinger J, Chatellard-Causse C, Blot B, Grange J, Schoehn G, Goldberg Y, Boyer V, Kirchhoff F, Raposo G, Garin J, Sadoul R
Journal name MCN
Publication year 2006
Sample Cortical neurones
Sample name Cortical neurones
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
2
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
3
Experiment ID 192
ISEV standards
CEM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
CD63|CD81|FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ubb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ubb is involved
No pathways found





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